MELITTIN
- CAS NO.:20449-79-0
- Empirical Formula: C131H229N39O31
- Molecular Weight: 2846.46
- MDL number: MFCD00076868
- EINECS: 629-303-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is MELITTIN?
The Uses of MELITTIN
Melittin has been used in standard bacterium-killing assay to determine bactericidal activity and study the role of melittin in allergic reactions.
The Uses of MELITTIN
Melittin from honey bee venom has been used:
- In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
- To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
- As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.
Definition
ChEBI: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active com onent of bee venom.
General Description
Chemical structure: peptide
Biochem/physiol Actions
Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death.
storage
Store at -20°C
Properties of MELITTIN
alpha | D21 -89.52° (c = 0.409) |
Density | 1.39 |
storage temp. | -20°C |
solubility | Soluble to 1 mg/ml in 20% acetonitrile |
form | White to faint tan powder. |
color | White to off-white |
Water Solubility | Soluble to 1 mg/ml in water |
Safety information for MELITTIN
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for MELITTIN
InChIKey | VDXZNPDIRNWWCW-JFTDCZMZSA-N |
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