Mecobalamin
Synonym(s):α-(5,6-Dimethylbenzimidazolyl)cyanocobamide;CN-Cbl;Cyanocob(III)alamin;Cyanocobalamin
- CAS NO.:13422-55-4
- Empirical Formula: C63H90CoN13O14P
- Molecular Weight: 1343.4
- MDL number: MFCD00082483
- EINECS: 236-535-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-28 16:55:20
What is Mecobalamin?
Description
Methylcobalamin is an analog of vitamin B12 with diverse neurological activities. It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 μM. Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine in a rat model of neuropathic pain. Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS). It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.
The Uses of Mecobalamin
One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic).
What are the applications of Application
Mecobalamin is a biologically active form of vitamin B12
Metabolism
Not Available
Properties of Mecobalamin
Melting point: | >190°C (dec.) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO (Slightly), Methanol (Sparingly), Water (Slightly) |
form | Solid |
color | Dark Red |
Water Solubility | Partially soluble in cold water, hot water. |
Safety information for Mecobalamin
Computed Descriptors for Mecobalamin
InChIKey | JEWJRMKHSMTXPP-WYVZQNDMSA-L |
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