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HomeProduct name listMaxacalcitol

Maxacalcitol

  • CAS NO.:103909-75-7
  • Empirical Formula: C26H42O4
  • Molecular Weight: 418.61
  • MDL number: MFCD00871502
  • EINECS: 234-317-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-21 15:02:05
Maxacalcitol Structural

What is Maxacalcitol?

Description

Maxacalcitol is the third synthetic vitamin D analog, after paricalcitol and doxercalciferol, to be marketed for the treatment of secondary hyperparathyroidism (SHPT) associated with chronic renal failure. It is a new vitamin D3 derivative with an oxygen atom in 22-position as main structural feature (22-oxacalcitriol, OCT). This vitamin D receptor agonist has a strong inhibitory effect on synthesis and secretion of parathyroid hormone in the setting of severe parathyroid hyperplasia. Maxacalcitol induced only minor effects on calcium and phosphate metabolism unlike an agent such as 1, 25(OH)2D3 that produced hypercalcemia and hyperphosphatemia. Maxacalcitol is.

Originator

Chugai (Japan)

The Uses of Maxacalcitol

22-Oxacalcitriol is the noncalcemic analogue of vitamine D and was found to suppress parathyroid hormone synthesis and secretion.

What are the applications of Application

22-Oxacalcitriol is a Vitamin D3 analog and VDR ligand

Definition

ChEBI: Maxacalcitol is an organic molecular entity.

brand name

Prezios (Chugai Pharmaceutical Co., Ltd., Japan);Prezios, Oxarol.

Properties of Maxacalcitol

Melting point: 122°
Boiling point: 581.4±50.0 °C(Predicted)
alpha  D20 +49.4° (c = l.00 in ethanol)
Density  1.09±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  Soluble in DMSO
form  crystalline solid
pka 14.43±0.40(Predicted)
color  White to off-white

Safety information for Maxacalcitol

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H301:Acute toxicity,oral
H361:Reproductive toxicity
Precautionary Statement Codes P281:Use personal protective equipment as required.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for Maxacalcitol

InChIKey DTXXSJZBSTYZKE-ZDQKKZTESA-N
SMILES [C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@@H](OCCC(O)(C)C)C)/C(=C)[C@@H](O)C1

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