Maxacalcitol
- CAS NO.：103909-75-7
- Empirical Formula: C26H42O4
- Molecular Weight: 418.61
- MDL number: MFCD00871502
- EINECS: 234-317-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-21 15:02:05
What is Maxacalcitol?
Description
Maxacalcitol is the third synthetic vitamin D analog, after paricalcitol and doxercalciferol, to be marketed for the treatment of secondary hyperparathyroidism (SHPT) associated with chronic renal failure. It is a new vitamin D3 derivative with an oxygen atom in 22-position as main structural feature (22-oxacalcitriol, OCT). This vitamin D receptor agonist has a strong inhibitory effect on synthesis and secretion of parathyroid hormone in the setting of severe parathyroid hyperplasia. Maxacalcitol induced only minor effects on calcium and phosphate metabolism unlike an agent such as 1, 25(OH)2D3 that produced hypercalcemia and hyperphosphatemia. Maxacalcitol is.
Originator
Chugai (Japan)
The Uses of Maxacalcitol
22-Oxacalcitriol is the noncalcemic analogue of vitamine D and was found to suppress parathyroid hormone synthesis and secretion.
What are the applications of Application
22-Oxacalcitriol is a Vitamin D3 analog and VDR ligand
Definition
ChEBI: Maxacalcitol is an organic molecular entity.
brand name
Prezios (Chugai Pharmaceutical Co., Ltd., Japan);Prezios, Oxarol.
Properties of Maxacalcitol
| Melting point: | 122° |
| Boiling point: | 581.4±50.0 °C(Predicted) |
| alpha | D20 +49.4° (c = l.00 in ethanol) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO |
| form | crystalline solid |
| pka | 14.43±0.40(Predicted) |
| color | White to off-white |
Safety information for Maxacalcitol
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H361:Reproductive toxicity |
| Precautionary Statement Codes |
P281:Use personal protective equipment as required. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for Maxacalcitol
| InChIKey | DTXXSJZBSTYZKE-ZDQKKZTESA-N |
| SMILES | [C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@@H](OCCC(O)(C)C)C)/C(=C)[C@@H](O)C1 |
Abamectin manufacturer
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