LY3214996
- CAS NO.：1951483-29-6
- Empirical Formula: C22H27N7O2S
- Molecular Weight: 453.56
- MDL number: MFCD31544324
- Update Date: 2024-07-02 08:55:11
What is LY3214996?
Description
LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.
Properties of LY3214996
| Boiling point: | 711.5±70.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM) Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM) |
| form | A crystalline solid |
| pka | 6.58±0.10(Predicted) |
| color | White to yellow |
Safety information for LY3214996
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for LY3214996
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin C Tubulysin A Tubulysin I Tubulysin M Tubulysin D Potassium HMDS (1.0 M in THF) 2-chloro-6-methylpyridin-4-amine 5-bromo-2-chloro-4-methyl-3-nitropyridine 2-cyano-6-chloro-3-nitropyridine S(-)Quinuclidine-2- Carbonitrile 3-fluoro2(Methyl amino)benzoic acid 5-bromo-2-chloroisonicotinic acid 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneRelated products of tetrahydrofuran
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