LY3023414
- CAS NO.:1386874-06-1
- Empirical Formula: C23H26N4O3
- Molecular Weight: 406.48
- MDL number: MFCD28411368
- Update Date: 2024-07-02 08:55:03
What is LY3023414?
Biological Activity
ly3023414 is an atp competitive inhibitor of the class i pi3k isoforms, mtor and dna-pk.the phosphoinositide-3 kinase (pi3k)/akt/mammalian target of rapamycin (mtor) pathway is one of the most frequently altered pathways in cancer cell growth and survival.
in vitro
in biochemical testing against approximately 266 kinases, ly3023414 was found to potently and selectively inhibit class i pi3k isoforms, mtorc1/2, as well as dna-pk at low concentrations. in addition, inhibition of pi3k/akt/mtor signaling by ly3023414 led to g1 cell-cycle arrest and resulted in broad antiproliferative activity in cancer cell panel [1].
in vivo
ly3023414 showed high bioavailability and dose-dependent dephosphorylation of pi3k/akt/mtor pathway downstream substrates for 4 to 6 hours, indicating ly3023414's half-life of 2 hours. moreover, equivalent total daily doses of ly3023414 given either once or twice daily could inhibit tumor growth to the similar extents in multiple xenograft models, demonstrating intermittent target inhibition was sufficient for antitumor activity [1].
References
[1] smith mc,mader mm,cook ja,et al. characterization of ly3023414, a novel pi3k/mtor dual inhibitor eliciting transient target modulation to impede tumor growth. mol cancer ther.2016 oct;15(10):2344-2356.
Properties of LY3023414
Boiling point: | 591.7±50.0 °C(Predicted) |
Density | 1.239±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≥40.6 mg/mL in DMSO; insoluble in H2O; ≥28.9 mg/mL in EtOH |
form | solid |
pka | 13.65±0.29(Predicted) |
color | Light yellow to yellow |
Safety information for LY3023414
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for LY3023414
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin F (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin G Tubulysin C 2-chloro-5-nitropyridin-4-amine 2-fluoro-5-(Methylsurfonyl)benzoic acid 2-chloro-4-fluoro-5-Iodobenzophenon 3-Amino tetra hydrofuran-3-carboxylic acid-n-butylester 5-bromo-1,4-dimethyl-3-nitropyridin-2(1H)-one (1-amino-cyclobutyl)-methanol Fuel shell Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3,3,6,6-Tetramethylcyclohexane-1,2-dioneRelated products of tetrahydrofuran
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