LY 334370 HYDROCHLORIDE
Synonym(s):4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate
- CAS NO.：182563-08-2
- Empirical Formula: C21H22FN3O
- Molecular Weight: 351.42
- MDL number: MFCD11519957
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-17 16:00:36
What is LY 334370 HYDROCHLORIDE?
The Uses of LY 334370 HYDROCHLORIDE
LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes.
What are the applications of Application
LY 334370 hydrochloride is a selective SR-1F agonist
Biological Activity
Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.
Properties of LY 334370 HYDROCHLORIDE
| Boiling point: | 479.1±45.0 °C(Predicted) |
| Density | 1.267±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | H2O: ≥5mg/mL (warmed) |
| form | powder |
| pka | 13.98±0.43(Predicted) |
| color | white to tan |
Safety information for LY 334370 HYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for LY 334370 HYDROCHLORIDE
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Diclofenac Potassium Ornidazole IP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Aceclofenac IP/BP/EP Nimesulide BP SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN SODIUM VALPROATE Racecadotril XANTHAN GUMRelated products of tetrahydrofuran
![Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2](https://img.chemicalbook.in/CAS/20211123/GIF/1088715-84-7.gif)
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