LY 334370 HYDROCHLORIDE
Synonym(s):4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate
- CAS NO.：182563-08-2
- Empirical Formula: C21H22FN3O
- Molecular Weight: 351.42
- MDL number: MFCD11519957
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is LY 334370 HYDROCHLORIDE?
The Uses of LY 334370 HYDROCHLORIDE
LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes.
What are the applications of Application
LY 334370 hydrochloride is a selective SR-1F agonist
Biological Activity
Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.
Properties of LY 334370 HYDROCHLORIDE
| Boiling point: | 479.1±45.0 °C(Predicted) |
| Density | 1.267±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | H2O: ≥5mg/mL (warmed) |
| form | powder |
| pka | 13.98±0.43(Predicted) |
| color | white to tan |
Safety information for LY 334370 HYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for LY 334370 HYDROCHLORIDE
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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