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HomeProduct name listLY 379268

LY 379268

LY 379268 Structural

What is LY 379268?

The Uses of LY 379268

LY 379268 is a group II metabotropic glutamate receptors (mGlu2/3) receptor agonist (1,2). Studies have shown that LY379268 significantly attenuated cocaine-induced increases in DA in nonhuman primates.

What are the applications of Application

LY 379268 is a highly selective group II mGlu receptor agonist

Definition

ChEBI: LY 379268 is an organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia. It has a role as a metabotropic glutamate receptor agonist, a neuroprotective agent, an antipsychotic agent and an anxiolytic drug. It is an organic heterobicyclic compound, a bridged compound and an amino dicarboxylic acid.

Biological Activity

Highly selective group II mGlu receptor agonist (EC 50 values are 2.69 and 4.48 nM for hmGlu 2 and hmGlu 3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active.

storage

Store at +4°C

Properties of LY 379268

Boiling point: 413.9±45.0 °C(Predicted)
Density  1.716±0.06 g/cm3(Predicted)
storage temp.  Store at +4°C
solubility  Soluble in H2O or NaOH
form  solid
pka 1.81±0.40(Predicted)
color  White
Water Solubility  Soluble to 20 mM in water and to 100 mM in 1eq. NaOH

Safety information for LY 379268

Computed Descriptors for LY 379268

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