LY 379268
- CAS NO.:191471-52-0
- Empirical Formula: C7H9NO5
- Molecular Weight: 187.15
- MDL number: MFCD11100365
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is LY 379268?
The Uses of LY 379268
LY 379268 is a group II metabotropic glutamate receptors (mGlu2/3) receptor agonist (1,2). Studies have shown that LY379268 significantly attenuated cocaine-induced increases in DA in nonhuman primates.
What are the applications of Application
LY 379268 is a highly selective group II mGlu receptor agonist
Definition
ChEBI: LY 379268 is an organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia. It has a role as a metabotropic glutamate receptor agonist, a neuroprotective agent, an antipsychotic agent and an anxiolytic drug. It is an organic heterobicyclic compound, a bridged compound and an amino dicarboxylic acid.
Biological Activity
Highly selective group II mGlu receptor agonist (EC 50 values are 2.69 and 4.48 nM for hmGlu 2 and hmGlu 3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active.
storage
Store at +4°C
Properties of LY 379268
Boiling point: | 413.9±45.0 °C(Predicted) |
Density | 1.716±0.06 g/cm3(Predicted) |
storage temp. | Store at +4°C |
solubility | Soluble in H2O or NaOH |
form | solid |
pka | 1.81±0.40(Predicted) |
color | White |
Water Solubility | Soluble to 20 mM in water and to 100 mM in 1eq. NaOH |
Safety information for LY 379268
Computed Descriptors for LY 379268
New Products
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