LY 303511
Synonym(s):2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V;LY 303511 - CAS 154447-38-8 - Calbiochem
- CAS NO.：154447-38-8
- Empirical Formula: C19H18N2O2
- Molecular Weight: 306.36
- MDL number: MFCD03453556
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:15
What is LY 303511?
The Uses of LY 303511
LY 303511 is an inactive analog of the phosphoinositide 3-kinase inhibitor LY294002.
What are the applications of Application
LY 303511 is a negative control for PI 3-kinase inhibitors
Definition
ChEBI: 8-phenyl-2-(1-piperazinyl)-1-benzopyran-4-one is a N-arylpiperazine.
Biological Activity
Negative control compound with respect to LY 294004 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-onehydrochloride ) PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (K v ) channels (IC 50 = 64.6 μ M) and inhibits IL-1 β -stimulated NF- κ B activation, attenuating MCP-1 expression. Anti-proliferative.
Properties of LY 303511
| Boiling point: | 496.1±45.0 °C(Predicted) |
| Density | 1.237±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO |
| pka | 9.20±0.10(Predicted) |
| form | Amber solid |
Safety information for LY 303511
Computed Descriptors for LY 303511
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