1-BOC-Piperazine
- CAS NO.:57260-71-6
- Empirical Formula: C9H18N2O2
- Molecular Weight: 186.25
- MDL number: MFCD00075265
- EINECS: 611-489-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-13 18:13:23
What is 1-BOC-Piperazine ?
Chemical properties
Waxy Solid
The Uses of 1-BOC-Piperazine
1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.
The Uses of 1-BOC-Piperazine
1-Boc-piperazine may be used in:
- preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
- termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
- preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors
What are the applications of Application
Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.
General Description
1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.
Properties of 1-BOC-Piperazine
Melting point: | 43-47 °C(lit.) |
Boiling point: | 98-100 |
Density | 1.030±0.06 g/cm3(Predicted) |
Flash point: | >230 °F |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | Soluble in DMSO |
pka | 8.45±0.10(Predicted) |
form | Low Melting Crystalline Mass |
color | White to light yellow |
Water Solubility | Soluble in ethyl acetate, methanol and water. |
Sensitive | Air Sensitive |
BRN | 879985 |
CAS DataBase Reference | 57260-71-6(CAS DataBase Reference) |
NIST Chemistry Reference | T-butyl 1-piperaziencarboxylate(57260-71-6) |
Safety information for 1-BOC-Piperazine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-BOC-Piperazine
InChIKey | CWXPZXBSDSIRCS-UHFFFAOYSA-N |
1-BOC-Piperazine manufacturer
Meenaakshi Molecules Pvt Ltd
Darshan Pharma Chem
Aruvi Labs
Noble Molecular Research
Aventus Labs
Rivashaa Agrotech Biopharma Pvt. Ltd.
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
N-Boc Piperazine 57260-71-6 98%View Details
57260-71-6 -
57260-71-6 1-Boc piperazine 98%View Details
57260-71-6 -
1-Boc-piperazine CAS 57260-71-6View Details
57260-71-6 -
57260-71-6 98%View Details
57260-71-6 -
1-Boc-piperazine, 97% CAS 57260-71-6View Details
57260-71-6 -
1-(tert-Butoxycarbonyl)piperazine CAS 57260-71-6View Details
57260-71-6 -
Tert-butyl-1-homopiperazine Carboxylate Chemical CAS 57260-71-6View Details
57260-71-6 -
t-Butyl piperazine-1-carboxylate 98% CAS 57260-71-6View Details
57260-71-6