Loxapine succinate salt

Description

Loxapine was first developed in the late 1960s and was introduced into clinical practice in the following decade. It is used primarily to treat the psychotic symptoms of schizophrenia. It is a member of the dibenzoxazepine class and is structurally related to clozapine. The introduction of newer antipsychotic agents has resulted in the reduced utilization of loxapine over the last few decades.

Description

Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α₁-adrenergic receptors (K_i values are 7, 7.7, 9.5, 12, and 31 nM for H₁, 5-HT_2A, 5-HT_2C, D₂, and α_1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.

Chemical properties

White to Of-White Solid

The Uses of Loxapine succinate salt

A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent

The Uses of Loxapine succinate salt

choleretic

The Uses of Loxapine succinate salt

Loxapine is used to treat and control the psychotic symptoms of both acute and chronic schizophrenia. Other uses include treatment of dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression. An inhalation powder of loxapine (Adasuve) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.

What are the applications of Application

Loxapine, Succinate is a D2DR, D4DR, and serotonin inhibitor

brand name

Loxapine (Mylan); Loxitane (Watson).

Toxicity evaluation

Loxapine has antagonistic action on alpha1 adrenergic, muscarinic, serotonergic, and dopaminergic receptors. It is thought to change the level of excitability in subcortical inhibitory areas of the brain by reducing the firing threshold of some polysynaptic neurons leading to seizure activity. Anticholinergic effects are also reported with loxapine intoxication.