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HomeProduct name listLOFEPRAMINE HYDROCHLORIDE

LOFEPRAMINE HYDROCHLORIDE

Synonym(s):N-(4-Chlorobenzoylmethyl)-3-(10,11-dihydro-5h-dibenz[b,f]azepin-5-yl)-n-methylpropylamine hydrochloride

  • CAS NO.:26786-32-3
  • Empirical Formula: C26H28Cl2N2O
  • Molecular Weight: 455.42
  • MDL number: MFCD00941486
  • EINECS: 248-002-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
LOFEPRAMINE HYDROCHLORIDE Structural

What is LOFEPRAMINE HYDROCHLORIDE?

Originator

Gamonil,E. Merck

The Uses of LOFEPRAMINE HYDROCHLORIDE

Lofepramine Hydrochloride is a tricyclic anti-depressent drug. Potent inhibitor of noradenaline uptake.

The Uses of LOFEPRAMINE HYDROCHLORIDE

Monoamine reuptake inhibitor; tricyclic antidepressant.

Definition

ChEBI: Lofepramine hydrochloride is a hydrochloride. It has a role as an antidepressant. It contains a lofepramine.

Manufacturing Process

9.8 parts of 10,11-dihydro-5H-dibenzo[b,f]azepine are dissolved in 10 parts of dry toluene and 3.1 parts of sodium amide are added and the mixture is refluxed and stirred for four hours. A solution of 13.5 parts of 1-(4- chlorophenyl)-2-[(3-chloropropyl)methylamino]ethanone in 20 parts of dry toluene is added dropwise and the mixture is stirred and refluxed for eight hours.
After cooling to room temperature water is carefully added to the reaction mixture and the toluene solution is extracted with water to which hydrochloric acid is added so that the aqueous phase obtains the pH-value of 5. The aqueous extract is discarded and the toluene phase is evaporated to dryness in vacuum. The residue is dissolved in 50 parts of methanol. Hydrogen gas is introduced to give the crystalline hydrochloride 1-(4-chlorophenyl)-2-((3- (10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)methylamino)ethanone; MP: 154°-156°C. The hydrochloride may be removed by adding an equivalent of any base (triethyl amine, sodium hydroxide and so on).

Therapeutic Function

Antidepressant

Properties of LOFEPRAMINE HYDROCHLORIDE

Melting point: 152-154°
Flash point: 9℃
storage temp.  2-8°C
solubility  DMSO: ~24 mg/mL
form  solid
color  off-white

Safety information for LOFEPRAMINE HYDROCHLORIDE

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H290:Corrosive to Metals
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for LOFEPRAMINE HYDROCHLORIDE

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