DESIPRAMINE HYDROCHLORIDE
Synonym(s):Desipramine hydrochloride
- CAS NO.:58-28-6
- Empirical Formula: C18H23ClN2
- Molecular Weight: 302.84
- MDL number: MFCD00058108
- EINECS: 200-373-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 13:44:46
What is DESIPRAMINE HYDROCHLORIDE?
Chemical properties
White To Off-White Solid
Originator
Pertofran,Geigy,UK,1963
The Uses of DESIPRAMINE HYDROCHLORIDE
Desipramine hydrochloride has been used:
- to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
- to protect unselective damage to the?noradrenergic system
- as a norepinephrine re-uptake inhibitor to treat rats for lesioning
The Uses of DESIPRAMINE HYDROCHLORIDE
Tricyclic antidepresant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
The Uses of DESIPRAMINE HYDROCHLORIDE
Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
What are the applications of Application
Desipramine hydrochloride is an inhibitor of norepinephrine, serotonin, and dopamine transporters
Definition
ChEBI: The hydrochloride salt of desipramine.
Manufacturing Process
Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced with hydrogen to the diamine. The diamine is pyrolyzed to give dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by reductive cleavage and then reacted with HCl.
brand name
Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis).
Therapeutic Function
Psychostimulant
General Description
The structure and salient properties of desipramine hydrochloride,10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride, 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride(Norpramin, Pertofrane), are discussed under the heading,Imipramine. Among tricyclics, desipramine would be consideredwhen few anticholinergic effects or a low level of sedationare important. It is a SNERI.
Biological Activity
Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
Biochem/physiol Actions
Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: decreased urine volume, sodium level changes, chlorine level changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO, and HCI.
storage
Desiccate at +4°C
Properties of DESIPRAMINE HYDROCHLORIDE
Melting point: | 214-2160C |
Flash point: | 11 °C |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL |
form | powder |
color | white to off-white |
Water Solubility | Soluble to 100 mM in water |
Safety information for DESIPRAMINE HYDROCHLORIDE
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DESIPRAMINE HYDROCHLORIDE
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