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HomeProduct name listDESIPRAMINE HYDROCHLORIDE

DESIPRAMINE HYDROCHLORIDE

Synonym(s):Desipramine hydrochloride

  • CAS NO.:58-28-6
  • Empirical Formula: C18H23ClN2
  • Molecular Weight: 302.84
  • MDL number: MFCD00058108
  • EINECS: 200-373-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 19:38:33
DESIPRAMINE HYDROCHLORIDE Structural

What is DESIPRAMINE HYDROCHLORIDE?

Chemical properties

White To Off-White Solid

Originator

Pertofran,Geigy,UK,1963

The Uses of DESIPRAMINE HYDROCHLORIDE

Desipramine hydrochloride has been used:

  • to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
  • to protect unselective damage to the?noradrenergic system
  • as a norepinephrine re-uptake inhibitor to treat rats for lesioning

The Uses of DESIPRAMINE HYDROCHLORIDE

Tricyclic antidepresant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.

The Uses of DESIPRAMINE HYDROCHLORIDE

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.

What are the applications of Application

Desipramine hydrochloride is an inhibitor of norepinephrine, serotonin, and dopamine transporters

Definition

ChEBI: The hydrochloride salt of desipramine.

Manufacturing Process

Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced with hydrogen to the diamine. The diamine is pyrolyzed to give dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by reductive cleavage and then reacted with HCl.

brand name

Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis).

Therapeutic Function

Psychostimulant

General Description

The structure and salient properties of desipramine hydrochloride,10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride, 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride(Norpramin, Pertofrane), are discussed under the heading,Imipramine. Among tricyclics, desipramine would be consideredwhen few anticholinergic effects or a low level of sedationare important. It is a SNERI.

Biological Activity

Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Biochem/physiol Actions

Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: decreased urine volume, sodium level changes, chlorine level changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO, and HCI.

storage

Desiccate at +4°C

Properties of DESIPRAMINE HYDROCHLORIDE

Melting point: 214-2160C
Flash point: 11 °C
storage temp.  2-8°C
solubility  H2O: 50 mg/mL
form  powder
color  white to off-white
Water Solubility  Soluble to 100 mM in water

Safety information for DESIPRAMINE HYDROCHLORIDE

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
H334:Sensitisation, respiratory
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DESIPRAMINE HYDROCHLORIDE

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