LM 22A4

Synonym(s):N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide

CAS NO.：37988-18-4
Empirical Formula: C15H21N3O6
Molecular Weight: 339.34
MDL number: MFCD00382831
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-30 15:45:59

What is LM 22A4?

Description

LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, LM22A-4 caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.1?Improves respiratory function in a mouse models of Rett syndrome.2

The Uses of LM 22A4

LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. LM 22A4 has been show to induce activation of Trk, Akt and ERK in mouse hippocampus and striatum and reverse deficits in motor task learning in mice following traumatic brain injury. LM 22A4 also restored respiratory function in a rat model of Rett syndrome.

storage

Store at +4°C

References

1) Massa et al. (2010), Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents; J. Clin. Invest., 120 1774 2) Schmid et al. (2012), A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome; J. Neurosci., 32 1803

Properties of LM 22A4

storage temp.	2-8°C
solubility	H2O: soluble2mg/mL, clear (warmed)
form	powder
color	white to beige
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.