LGK-974
Synonym(s):2-(2ʹ,3-Dimethyl-2,4ʹ-bipyridin-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide, Wnt Pathway Inhibitor XXIII, LGK-974;Porcn Inhibitor IV, LGK974 - CAS 1243244-14-5 - Calbiochem
- CAS NO.:1243244-14-5
- Empirical Formula: C23H20N6O
- Molecular Weight: 396.44
- MDL number: MFCD27501026
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-29 17:14:30
What is LGK-974?
Description
Porcupine (PORCN) is a membrane bound O-
The Uses of LGK-974
LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.
What are the applications of Application
LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor
Definition
ChEBI: LGK974 is a carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). It has a role as a Wnt signalling inhibitor. It is a member of bipyridines, a member of pyrazines, a member of pyridines and a secondary carboxamide. It is functionally related to an acetamide.
References
[1] liu j, pan s, hsieh mh, ng n, sun f, wang t, kasibhatla s, schuller ag, li ag, cheng d, li j, tompkins c, pferdekamper a, steffy a, cheng j, kowal c, phung v, guo g, wang y, graham mp, flynn s, brenner jc, li c, villarroel mc, schultz pg, wu x, mcnamara p, sellers wr, petruzzelli l, boral al, seidel hm, mclaughlin me, che j, carey te, vanasse g, harris jl. targeting wnt-driven cancer through the inhibition of porcupine by lgk974. proc natl acad sci u s a. 2013 dec 10;110(50):20224-9.
Properties of LGK-974
Melting point: | 176 - 180°C |
Boiling point: | 650.9±55.0 °C(Predicted) |
Density | 1.268±0.06 g/cm3(Predicted) |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 12.24±0.70(Predicted) |
color | White to Off-White |
Safety information for LGK-974
Computed Descriptors for LGK-974
New Products
Tubulysin C Tubulysin D Tubulysin E Tubulysin F (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 4-(Benzyloxy)-3-bromophenylacetic Acid 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 3-Aminocyclobutanone hydrochloride 1-(1,1-Difluoroethyl)-2-fluorobenzene 2,2-Difluoropropanol Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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