N,N-Dimethylbenzamide

CAS NO.：611-74-5
Empirical Formula: C9H11NO
Molecular Weight: 149.19
MDL number: MFCD00008320
EINECS: 210-279-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-11 17:44:06

What is N,N-Dimethylbenzamide?

Chemical properties

white to slightly yellow cryst. low melting solid

The Uses of N,N-Dimethylbenzamide

Reagent for deoxygenation of secondary alcohols.

What are the applications of Application

N,N-Dimethylbenzamide is a reagent for secondary alcohol deoxygenation

Synthesis Reference(s)

The Journal of Organic Chemistry, 36, p. 2721, 1971 DOI: 10.1021/jo00817a036
Journal of the American Chemical Society, 77, p. 1114, 1955 DOI: 10.1021/ja01610a010
Synthetic Communications, 12, p. 989, 1982 DOI: 10.1080/00397918208061938

General Description

N,N-Dimethylbenzamide is a hydrotropic agent and its ability to solubilize drugs with low aqueous solubility has been investigated. It reacts with PhLnI complexes (Ln-Eu, Sm, Yb) to yield benzophenone in good yields. Deuterium exchange labelling experimets on N,N-dimethylbenzamide using [IrH₂(Me₂CO)₂(PPh₃)₂]BF₄as catalyst and deuterium gas as the source of isotope has been conducted.

Properties of N,N-Dimethylbenzamide

Melting point:	43-45 °C (lit.)
Boiling point:	132-133 °C/15 mmHg (lit.)
Density	1.0753 (rough estimate)
refractive index	1.5279 (estimate)
Flash point:	>230 °F
storage temp.	2-8°C(protect from light)
pka	-1.14±0.70(Predicted)
form	powder to lump to clear liquid
color	White or Colorless to Light yellow
Water Solubility	Soluble in water.
BRN	774955
CAS DataBase Reference	611-74-5(CAS DataBase Reference)
NIST Chemistry Reference	Benzamide, N,N-dimethyl-(611-74-5)
EPA Substance Registry System	Benzamide, N,N-dimethyl- (611-74-5)

Safety information for N,N-Dimethylbenzamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.