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HomeProduct name listLAVENDUSTIN A

LAVENDUSTIN A

Synonym(s):5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355;Lavendustin A - CAS 125697-92-9 - Calbiochem

LAVENDUSTIN A Structural

What is LAVENDUSTIN A?

Description

Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.

Chemical properties

Off-White Solid

The Uses of LAVENDUSTIN A

A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide

The Uses of LAVENDUSTIN A

A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.

What are the applications of Application

Lavendustin A is a selective and potent inhibitor of the receptor tyrosine kinase

Definition

ChEBI: 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid is an aromatic amine.

Biological Activity

Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M).

Properties of LAVENDUSTIN A

Melting point: 205-215 °C
Boiling point: 741.7±60.0 °C(Predicted)
Density  1.495±0.06 g/cm3(Predicted)
RTECS  DG8578950
storage temp.  −20°C
solubility  DMSO: soluble
form  crystalline
pka 2.31±0.10(Predicted)
color  Yellow to brown
Sensitive  Air Sensitive
Stability: Moisture Sensitive: Hygroscopic
CAS DataBase Reference 125697-92-9(CAS DataBase Reference)

Safety information for LAVENDUSTIN A

Computed Descriptors for LAVENDUSTIN A

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