LAVENDUSTIN A
Synonym(s):5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355;Lavendustin A - CAS 125697-92-9 - Calbiochem
- CAS NO.:125697-92-9
- Empirical Formula: C21H19NO6
- Molecular Weight: 381.38
- MDL number: MFCD00153822
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:16
What is LAVENDUSTIN A?
Description
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.
Chemical properties
Off-White Solid
The Uses of LAVENDUSTIN A
A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide
The Uses of LAVENDUSTIN A
A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.
What are the applications of Application
Lavendustin A is a selective and potent inhibitor of the receptor tyrosine kinase
Definition
ChEBI: 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid is an aromatic amine.
Biological Activity
Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M).
Properties of LAVENDUSTIN A
Melting point: | 205-215 °C |
Boiling point: | 741.7±60.0 °C(Predicted) |
Density | 1.495±0.06 g/cm3(Predicted) |
RTECS | DG8578950 |
storage temp. | −20°C |
solubility | DMSO: soluble |
form | crystalline |
pka | 2.31±0.10(Predicted) |
color | Yellow to brown |
Sensitive | Air Sensitive |
Stability: | Moisture Sensitive: Hygroscopic |
CAS DataBase Reference | 125697-92-9(CAS DataBase Reference) |
Safety information for LAVENDUSTIN A
Computed Descriptors for LAVENDUSTIN A
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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