L-SEPIAPTERIN
Synonym(s):S-(−)-2-Amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-pteridinone;L -Sepiapterin
- CAS NO.：17094-01-8
- Empirical Formula: C9H11N5O3
- Molecular Weight: 237.22
- MDL number: MFCD00210214
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-25 10:25:48
What is L-SEPIAPTERIN?
Chemical properties
yellow to orange powder
The Uses of L-SEPIAPTERIN
L-Sepiapterin serves as a substrate for BH4 synthesis via the pterin salvage pathway. It inhibits rat liver GTP cyclohydrolase with an IC50 value of approximately 25 μM. It can be used to circumvent the inhibition of pterin biosynthesis by 2,4-diamino-6-hydroxy pyrimidine.[Cayman Chemical]
The Uses of L-SEPIAPTERIN
Sepiapterin improved the endothelial dysfunction in SMA from db?/db mice by decreasing oxidative stress. Sepiapterin is commonly used in the study for treamtment of Type I Diabetes
The Uses of L-SEPIAPTERIN
Sepiapterin can be used to induce sequence-specific photolesions in double-stranded DNA.
What are the applications of Application
An intermediate in the salvage pathway of tetrahydrobiopterin
Definition
ChEBI: L-sepiapterin is a sepiapterin with L configuration.
General Description
Sepiapterin, a pteridine derivative, is a stable precursor of tetrahydrobiopterin (BH4). It is a yellow pigment found in sepia mutant of Drosophila melanogaster and lemon Bombyx mori mutant (silkworm).
Biochem/physiol Actions
Cofactor of nitric oxide synthase; intracellularly converted to tetrahydro-biopterin leading to the stimulation of nitric oxide.
Properties of L-SEPIAPTERIN
| Melting point: | >270 °C (dec.) |
| Boiling point: | 448.1±55.0 °C(Predicted) |
| Density | 1.86±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 27 mg/mL |
| form | solid |
| pka | 12.33±0.20(Predicted) |
| color | yellow |
| Stability: | Light Sensitive |
| CAS DataBase Reference | 17094-01-8 |
Safety information for L-SEPIAPTERIN
Computed Descriptors for L-SEPIAPTERIN
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