2-Amino-4-hydroxy-1H-pteridine

Synonym(s):2-Amino-4-hydroxypteridine;2-Amino-4-oxodihydropteridine

CAS NO.：2236-60-4
Empirical Formula: C6H5N5O
Molecular Weight: 163.14
MDL number: MFCD00010557
EINECS: 218-799-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:36

2-Amino-4-hydroxy-1H-pteridine Structural

What is 2-Amino-4-hydroxy-1H-pteridine?

Chemical properties

YELLOW-BEIGE CRYSTALLINE POWDER

The Uses of 2-Amino-4-hydroxy-1H-pteridine

Pterin is used in the biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.

Definition

ChEBI: 2-aminopteridin-4-ol is a 2-amino-4-hydroxypteridine. It is a tautomer of a 2-aminopteridin-4(3H)-one and a 2-aminopteridin-4(1H)-one.

Purification Methods

It is dissolved in hot 1% aqueous ammonia, filtered, and an equal volume of hot 1M aqueous formic acid is added. The solution is allowed to cool at 0-2o overnight. The solid is collected and washed with distilled water several times by centrifugation and dried in vacuo over P2O5 overnight, and then at 100o overnight (any ammonium formate in the sample evaporates off). [Beilstein 26 III/IV 3936.]

Properties of 2-Amino-4-hydroxy-1H-pteridine

Melting point:	300 °C
Boiling point:	290.2°C (rough estimate)
Density	1.4240 (rough estimate)
refractive index	1.9000 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
pka	2.27(at 20℃)
Water Solubility	17.54mg/L(22.5 ºC)
BRN	150294
CAS DataBase Reference	2236-60-4(CAS DataBase Reference)
NIST Chemistry Reference	4(1H)-pteridinone, 2-amino-(2236-60-4)

Safety information for 2-Amino-4-hydroxy-1H-pteridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.