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HomeProduct name listL-Phenylglycine

L-Phenylglycine

Synonym(s):(S)-(+)-2-Phenylglycine;S-(+)-α-Aminophenylacetic acid;L-2-Phenylglycine

  • CAS NO.:2935-35-5
  • Empirical Formula: C8H9NO2
  • Molecular Weight: 151.16
  • MDL number: MFCD00064403
  • EINECS: 220-909-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:48
L-Phenylglycine Structural

What is L-Phenylglycine?

Description

L-Phenylglycine is an amide that belongs to the group of pyridoxal phosphate analogues. It has been shown to be a response element for enzymes and natural compounds in Escherichia coli and Saccharomyces cerevisiae. It inhibits aminotransferase activity, dopamine synthesis, and microbial metabolism in these organisms. This compound also has a structural analysis that includes x-ray diffraction data, which can be used to identify its three-dimensional structure.

Chemical properties

White crystalline powder

The Uses of L-Phenylglycine

L-(+)-2-Phenylglycine is a derivative of Glycine (G615990), the smallest of all the amino acids, and is also used to treat schizophrenia, stroke, and benign prostatic hyperplasia. L-(+)-2-Phenylglycine is also used as an N-linked side chain of an SMTP (Stachybotrys microspora tripenyl phenols) congener, which was potent in enhancing plasminogen activation in S. microspora.

Definition

ChEBI: The S stereoisomer of alpha-phenylglycine.

Purification Methods

Crystallise it from EtOH. [Kaneko J Chem Soc Jpn 60 538 1939, Rudman et al. J Am Chem Soc 74 551 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2694-2697 1961, Beilstein 14 III 1187, 14 IV 1317.]

Properties of L-Phenylglycine

Melting point: >300 °C(lit.)
alpha  157 º (c=2, 2N HCl)
Boiling point: 273.17°C (rough estimate)
Density  1.2023 (rough estimate)
refractive index  158 ° (C=1, 1mol/L HCl)
Flash point: 150 °C
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Aqueous Acid, Aqueous Base
pka 1.83(at 25℃)
form  Fine Crystalline Powder
color  White
optical activity [α]20/D +155°, c = 1 in 1 M HCl
Merck  14,7291
BRN  2208675
CAS DataBase Reference 2935-35-5(CAS DataBase Reference)
EPA Substance Registry System L-Phenylglycine (2935-35-5)

Safety information for L-Phenylglycine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for L-Phenylglycine

InChIKey ZGUNAGUHMKGQNY-ZETCQYMHSA-N

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