4-Hydroxy-D-(-)-2-phenylglycine
Synonym(s):(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid;4-Hydroxy-D -phenylglycine;Cefadroxyl impurity A
- CAS NO.：22818-40-2
- Empirical Formula: C8H9NO3
- Molecular Weight: 167.16
- MDL number: MFCD00004262
- EINECS: 245-247-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is 4-Hydroxy-D-(-)-2-phenylglycine?
Description
d-(p-Hydroxyphenyl)glycine (d-HPG) is widely used in large amounts as an important intermediate for the synthesis of amoxicillin and several other semisynthetic β-lactam antibiotics.
Chemical properties
off-white powder
The Uses of 4-Hydroxy-D-(-)-2-phenylglycine
4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
The Uses of 4-Hydroxy-D-(-)-2-phenylglycine
4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
Definition
ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.
Flammability and Explosibility
Non flammable
Purification Methods
Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]
Properties of 4-Hydroxy-D-(-)-2-phenylglycine
| Melting point: | 240 °C (dec.)(lit.) |
| Boiling point: | 295.73°C (rough estimate) |
| alpha | -156 º (c=1, 1 N HCl) |
| Density | 1.396 |
| vapor pressure | 0Pa at 25℃ |
| refractive index | -158 ° (C=1, 1mol/L HCl) |
| storage temp. | 2-8°C |
| solubility | 5g/l |
| form | Liquid |
| pka | 2.15±0.10(Predicted) |
| color | Clear colorless to yellow |
| optical activity | [α]23/D 158±3°, c = 1 in 1 M HCl |
| Water Solubility | 5 g/L (20 ºC) |
| BRN | 2210998 |
| CAS DataBase Reference | 22818-40-2(CAS DataBase Reference) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2) |
Safety information for 4-Hydroxy-D-(-)-2-phenylglycine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4-Hydroxy-D-(-)-2-phenylglycine
4-Hydroxy-D-(-)-2-phenylglycine manufacturer
Allmpus Laboratories Pvt Ltd
1Y
Phone:+91-9167862134
Whatsapp: +91-9167862134
product: 22818-40-2 AMOXICILLIN EP IMPURITY I | AMOXICILLIN USP RC I 97.94
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