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HomeProduct name listL-NIO DIHYDROCHLORIDE

L-NIO DIHYDROCHLORIDE

Synonym(s):L-NIO hydrochloride;L-Ornithine ψ-acetamidine hydrochloride

L-NIO DIHYDROCHLORIDE Structural

What is L-NIO DIHYDROCHLORIDE?

Description

L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.

Chemical properties

White Crystalline Solid

The Uses of L-NIO DIHYDROCHLORIDE

A potent and reversible inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

What are the applications of Application

L-NIO dihydrochloride is a potent inhibitor of NOS1, NOS2, and NOS3

Definition

ChEBI: L-NIO is a L-alpha-amino acid.

Biological Activity

Potent inhibitor of endothelial NO synthase (IC 50 = 500 nM). Also inhibits iNOS and nNOS. Active in vivo .

Properties of L-NIO DIHYDROCHLORIDE

Melting point: 225-226°C
storage temp.  -20°C
solubility  Methanol (Slightly), Water (Slightly)
form  Solid
color  White to Off-White
Stability: Hygroscopic

Safety information for L-NIO DIHYDROCHLORIDE

Computed Descriptors for L-NIO DIHYDROCHLORIDE

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