L-LEUCIC ACID
Synonym(s):L -2-Hydroxy-4-methylpentanoic acid;L -Leucic acid;2-Hydroxy-4-methylvaleric acid
- CAS NO.：13748-90-8
- Empirical Formula: C6H12O3
- Molecular Weight: 132.16
- MDL number: MFCD00064214
- EINECS: 237-329-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is L-LEUCIC ACID?
Chemical properties
white to light yellow crystal powde
The Uses of L-LEUCIC ACID
L-Leucic Acid is a reagent in the synthesis of cryptophycins based macrocyclic depsipeptides which are used as tubulin inhibitors.
Definition
ChEBI: The (S)-enantiomer of 2-hydroxy-4-methylpentanoic acid. Derived from the metabolism of the branched-chain amino acids, it belongs to the 2-hydroxycarboxylic acid group of amino acid metabolites.
Properties of L-LEUCIC ACID
| Melting point: | 78-80 °C(lit.) |
| Boiling point: | 277.83°C (rough estimate) |
| Density | 1.0160 (rough estimate) |
| refractive index | -26 ° (C=2, 1 %NaOH) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Aqueous Base (Slightly), DMSO (Sparingly), Water (Slightly) |
| form | Solid |
| pka | 3.86±0.21(Predicted) |
| color | White to Off-White |
| optical activity | [α]22/D 26.3°, c = 1 in 1 M NaOH |
| Water Solubility | almost transparency |
| CAS DataBase Reference | 13748-90-8(CAS DataBase Reference) |
| EPA Substance Registry System | Pentanoic acid, 2-hydroxy-4-methyl-, (2S)- (13748-90-8) |
Safety information for L-LEUCIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for L-LEUCIC ACID
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