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HomeProduct name listL(+)-Homoarginine hydrochloride

L(+)-Homoarginine hydrochloride

Synonym(s):(S)-2-Amino-6-guanidinohexanoic acid hydrochloride

  • CAS NO.:1483-01-8
  • Empirical Formula: C7H17ClN4O2
  • Molecular Weight: 224.69
  • MDL number: MFCD00012622
  • EINECS: 216-045-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-07 21:39:59
L(+)-Homoarginine hydrochloride Structural

What is L(+)-Homoarginine hydrochloride?

Description

L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases. This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells. Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.

Chemical properties

White Powder

The Uses of L(+)-Homoarginine hydrochloride

An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).

The Uses of L(+)-Homoarginine hydrochloride

An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

What are the applications of Application

L-Homoarginine Hydrochloride is an inhibitor of alkaline phosphatase isoenzymes

Biochem/physiol Actions

Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.

Properties of L(+)-Homoarginine hydrochloride

Melting point: 213-215 °C(lit.)
alpha  18 º (c=1, 1N HCl)
storage temp.  Inert atmosphere,Room Temperature
solubility  H2O: 50 mg/mL, clear to slightly hazy, faintly yellow
form  Granular Powder
color  White
Water Solubility  Soluble in water(50 mg/mL).
BRN  4016621
Stability: Moisture Sensitive
CAS DataBase Reference 1483-01-8(CAS DataBase Reference)

Safety information for L(+)-Homoarginine hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for L(+)-Homoarginine hydrochloride

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