L(+)-Homoarginine hydrochloride

Synonym(s):(S)-2-Amino-6-guanidinohexanoic acid hydrochloride

CAS NO.：1483-01-8
Empirical Formula: C7H17ClN4O2
Molecular Weight: 224.69
MDL number: MFCD00012622
EINECS: 216-045-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

L(+)-Homoarginine hydrochloride Structural

What is L(+)-Homoarginine hydrochloride?

Description

L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases. This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [³H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells. Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.

Chemical properties

White Powder

The Uses of L(+)-Homoarginine hydrochloride

An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).

The Uses of L(+)-Homoarginine hydrochloride

An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

What are the applications of Application

L-Homoarginine Hydrochloride is an inhibitor of alkaline phosphatase isoenzymes

Biochem/physiol Actions

Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.

Properties of L(+)-Homoarginine hydrochloride

Melting point:	213-215 °C(lit.)
alpha	18 º (c=1, 1N HCl)
storage temp.	Inert atmosphere,Room Temperature
solubility	H₂O: 50 mg/mL, clear to slightly hazy, faintly yellow
form	Granular Powder
color	White
Water Solubility	Soluble in water(50 mg/mL).
BRN	4016621
Stability:	Moisture Sensitive
CAS DataBase Reference	1483-01-8(CAS DataBase Reference)

Safety information for L(+)-Homoarginine hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.