L(+)-Homoarginine hydrochloride
Synonym(s):(S)-2-Amino-6-guanidinohexanoic acid hydrochloride
- CAS NO.：1483-01-8
- Empirical Formula: C7H17ClN4O2
- Molecular Weight: 224.69
- MDL number: MFCD00012622
- EINECS: 216-045-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is L(+)-Homoarginine hydrochloride?
Description
L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases. This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells. Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.
Chemical properties
White Powder
The Uses of L(+)-Homoarginine hydrochloride
An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).
The Uses of L(+)-Homoarginine hydrochloride
An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.
What are the applications of Application
L-Homoarginine Hydrochloride is an inhibitor of alkaline phosphatase isoenzymes
Biochem/physiol Actions
Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.
Properties of L(+)-Homoarginine hydrochloride
| Melting point: | 213-215 °C(lit.) |
| alpha | 18 º (c=1, 1N HCl) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 50 mg/mL, clear to slightly hazy, faintly yellow |
| form | Granular Powder |
| color | White |
| Water Solubility | Soluble in water(50 mg/mL). |
| BRN | 4016621 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 1483-01-8(CAS DataBase Reference) |
Safety information for L(+)-Homoarginine hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for L(+)-Homoarginine hydrochloride
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