Homoarginine
- CAS NO.:156-86-5
- Empirical Formula: C7H16N4O2
- Molecular Weight: 188.23
- MDL number: MFCD00237108
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Homoarginine?
Description
Homoarginine and 1-hydroxyhomoarginine were originally detected in significant concentration in the seeds of many Lathyrus species (Bell, 1962a,b; 1963). Homoarginine was isolated from the seeds of L. cicera (Bell, 1962b) and L. sativus (Rao et al., 1963). The hydroxy compound was obtained from the seeds of L. tingitanus (Bell, 1964). The comparative distribution of guanidino compounds in the seeds of two genus of the Papilionoideae, Lathyrus and Vicia, exhibits interesting features (Bell and Tirimanna, 1964). For example, the genus Lathyrus stores predominantly the C7 amino acids homoarginine, y-hydroxyhomoarginine and the related compound lathyrine, while the genus Vicia stores relatively high concentrations of canavanine and of the C6 amino acids arginine and y-hydroxyarginine. Apart from plants, homoarginine was found in small amounts in human body fluids ,. urine (Armstrong, 1967), serum (Matsumoto et al., 1976a) and cerebrospinal fluid (Mori et al., 1981b) and in mammalian brain (Mori et al., 1978, 1979 ). Increased urinary excretion was reported in hyperlysinemia (Armstrong and Robinow, 1967) and citrullinemia (Scott-Emuakpor et al., 19(2).
Homoarginine may be formed in mammals from lysine, by a homologous urea cycle in which arginine is replaced by lysine (Ryan and Wells, 1964; Scott-Emuakpor et al., 19(2). The excretion of homocitrulline and homoarginine in urine following administration of lysine to children supports this theory (Buergi et al., 1966). The biosynthesis of homoarginine has not been examined in plants, but y-hydroxyhomoarginine is synthesized from homoarginine in Lathyrus seeds (Bell, 1964). Subsequently both compounds have been identified as the precursors of the cyclic guanidino derivative, lathyrine, also present in Lathyrus seeds (Bell and Przybylska, 1965). Homoarginine and y-hydroxyhomoarginine probably serve as nitrogen reserves in Lathyrus seeds.
Inhibition of growth by homoarginine has been reported In various microorganisms (Walker, 1955; Rao et al., 1963).
gama-Hydroxyhomoarginine lactone isolated from the seeds of L. tingitanus (Bell, 1964) probably results from the cyclization of the open chain compound under acidic conditions.
Chemical properties
White to off-white powder
The Uses of Homoarginine
Homoarginine as marker for exogenous protein
Absorption and secretion of free homoarginine in the intestine: when 9 mmol homoarginine were infused into the proximal part of the jejunum, there was a 99.9% disappearance of the free amino acid homoarginine up to the ileum. In addition, following the infusion of 9 mmol homoarginine into the vena jugularis less than 0.2% of the infused homoarginine appeared in the intestine.
We concluded from these data that with the homoarginine method endogenous protein in the chyme of the intestine can be distinguished from the food protein as homoarginine is not incorporated into endogenous secreta and free homo arginine is completely absorbed.
The Uses of Homoarginine
Homoarginine is an inhibitor of human arginase activity.
Definition
ChEBI: An L-lysine derivative that is the L-enantiomer of homoarginine.
Properties of Homoarginine
Melting point: | 207-209 °C |
Boiling point: | 376.3±52.0 °C(Predicted) |
Density | 1.39±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
form | Powder |
pka | 2.52±0.24(Predicted) |
color | White to off-white |
CAS DataBase Reference | 156-86-5(CAS DataBase Reference) |
Safety information for Homoarginine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P330:Rinse mouth. P363:Wash contaminated clothing before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P501:Dispose of contents/container to..… |
Computed Descriptors for Homoarginine
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JSK Chemicals
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