L-AP4
Synonym(s):L -AP-4;Cartilage-Derived Morphogenetic Protein-1;CDMP-1;LAP4;L-AP4
- CAS NO.:23052-81-5
- Empirical Formula: C4H10NO5P
- Molecular Weight: 183.1
- MDL number: MFCD00083244
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is L-AP4?
Description
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-
Chemical properties
white to off-white crystalline powder
The Uses of L-AP4
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.
The Uses of L-AP4
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is a mGluR-4/6 receptor agonist.
What are the applications of Application
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is a mGluR-4/6 receptor agonist
Definition
ChEBI: (2S)-2-amino-4-phosphonobutanoic acid is a non-proteinogenc L-alpha-amino acid that is L-alpha-aminobutyric acid in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It is a potent and selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It has a role as a metabotropic glutamate receptor agonist. It is a non-proteinogenic L-alpha-amino acid and a member of phosphonic acids.
Biological Activity
Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
storage
Room temperature
Properties of L-AP4
Melting point: | 207-215 °C |
Boiling point: | 491.7±55.0 °C(Predicted) |
Density | 1.628±0.06 g/cm3(Predicted) |
storage temp. | 0-6°C |
solubility | H2O : 50 mg/mL (273.07 mM; Need ultrasonic) |
pka | 2.19±0.10(Predicted) |
form | solid |
color | White |
Water Solubility | Soluble to 5 mM in water and to 100 mM in 1eq. NaOH |
Sensitive | Light Sensitive |
CAS DataBase Reference | 23052-81-5(CAS DataBase Reference) |
Safety information for L-AP4
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for L-AP4
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