KU57788(NU7441)
- CAS NO.:503468-95-9
- Empirical Formula: C25H19NO3S
- Molecular Weight: 413.49
- MDL number: MFCD11983069
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-30 18:52:02
What is KU57788(NU7441)?
Description
DNA-
The Uses of KU57788(NU7441)
A potent novel DNA-dependent protein kinase inhibitor models of human cancer
The Uses of KU57788(NU7441)
A potent and selective DNA-PK inhibitor with an IC50 of 14 nM.
The Uses of KU57788(NU7441)
A potent novel DNA-dependent protein kinase inhibitor models of human cancer. Antitumor agent.
What are the applications of Application
NU 7441 is a DNA-PK inhibitor, and antitumor agent in vitro
Definition
ChEBI: 8-(4-dibenzothiophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of dibenzothiophenes.
storage
Store at +4°C
References
1) Leahy?et al.?(2004),?Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries; Bioorg. Med. Chem. Lett.,?14?6083 2) Hardcastle?et al.?(2005),?Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach: J. Med. Chem.,?48?7829 3) Zhao?et al.?(2006),?Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441: Cancer Res.?66?5354 4) Ciszewski?et al.?(2014),?DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin: Breast Cancer Res. Treat.,?143?83 5) Yang?et al.?(2016),?NU7441 Enhances the Radiosensitivity of Liver Cancer Cells: Cell Physiol. Biochem.,?38?1897 6) Geng?et al.?(2019),?DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy: Oncol. Rep.,?42?561
Properties of KU57788(NU7441)
Melting point: | 220-221 °C |
Boiling point: | 646.9±55.0 °C(Predicted) |
Density | 1.376±0.06 g/cm3(Predicted) |
storage temp. | Store at +4°C |
solubility | Soluble in DMSO (up to 10 mg/ml with warming). |
form | solid |
pka | 0.51±0.20(Predicted) |
color | Off-white to beige |
Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for KU57788(NU7441)
Computed Descriptors for KU57788(NU7441)
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen 4-((2-isopropoxyethoxy)methyl)phenol 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid 1,2,3,4-Tetrahydrocarbazol-4-one Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride Methyl Di Chloride (Mdc) 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/Related products of tetrahydrofuran
You may like
-
KU57788 >95% CAS 503468-95-9View Details
503468-95-9 -
Nu 7441 95% CAS 503468-95-9View Details
503468-95-9 -
NU7441 CAS 503468-95-9View Details
503468-95-9 -
7726-95-6 Bromine 99.5% AR (4 x 500ml) 99%View Details
7726-95-6 -
Formamide 99%View Details
75-12-7 -
85-81-4 6-Methoxy-8-Nitroquinoline 99%View Details
85-81-4 -
3-Bromo-4,5-Dihydro-1H-Benzo[B]Azepin-2(3H)-One 99%View Details
86499-96-9 -
(−)-Dip-Chloride 85116-37-6 99%View Details
85116-37-6