KU57788(NU7441)
- CAS NO.:503468-95-9
- Empirical Formula: C25H19NO3S
- Molecular Weight: 413.49
- MDL number: MFCD11983069
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is KU57788(NU7441)?
Description
DNA-
The Uses of KU57788(NU7441)
A potent novel DNA-dependent protein kinase inhibitor models of human cancer
The Uses of KU57788(NU7441)
A potent and selective DNA-PK inhibitor with an IC50 of 14 nM.
The Uses of KU57788(NU7441)
A potent novel DNA-dependent protein kinase inhibitor models of human cancer. Antitumor agent.
What are the applications of Application
NU 7441 is a DNA-PK inhibitor, and antitumor agent in vitro
Definition
ChEBI: 8-(4-dibenzothiophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of dibenzothiophenes.
storage
Store at +4°C
References
1) Leahy?et al.?(2004),?Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries; Bioorg. Med. Chem. Lett.,?14?6083 2) Hardcastle?et al.?(2005),?Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach: J. Med. Chem.,?48?7829 3) Zhao?et al.?(2006),?Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441: Cancer Res.?66?5354 4) Ciszewski?et al.?(2014),?DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin: Breast Cancer Res. Treat.,?143?83 5) Yang?et al.?(2016),?NU7441 Enhances the Radiosensitivity of Liver Cancer Cells: Cell Physiol. Biochem.,?38?1897 6) Geng?et al.?(2019),?DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy: Oncol. Rep.,?42?561
Properties of KU57788(NU7441)
Melting point: | 220-221 °C |
Boiling point: | 646.9±55.0 °C(Predicted) |
Density | 1.376±0.06 g/cm3(Predicted) |
storage temp. | Store at +4°C |
solubility | Soluble in DMSO (up to 10 mg/ml with warming). |
form | solid |
pka | 0.51±0.20(Predicted) |
color | Off-white to beige |
Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for KU57788(NU7441)
Computed Descriptors for KU57788(NU7441)
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin I Tubulysin C 2,2-diethoxyethanethioamide 4,4-DIFLUOROPIPERIDINE 2H-Pyran, 4-ethynyltetrahydro- 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2,2-Difluoropropylamine hydrochloride 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 3-Aminocyclobutanone hydrochloride Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (+/-)-6-Acetylamino-2- amino-4, 5, 6, 7-tetrahydro Benzo thiazole (R)-1-Aminoindan Hydrochloride Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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