NU7026
Synonym(s):DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem;NU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646
- CAS NO.：154447-35-5
- Empirical Formula: C17H15NO3
- Molecular Weight: 281.31
- MDL number: MFCD06798345
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is NU7026?
The Uses of NU7026
NU7026 has been used:
- as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
- in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
- to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells
The Uses of NU7026
DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK.
What are the applications of Application
DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK
Definition
ChEBI: 2-(4-morpholinyl)-4-benzo[h][1]benzopyranone is an organooxygen compound and an organic heterotricyclic compound.
Biological Activity
ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC 50 values are 0.23, 13.0, > 100 and > 100 μ M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
Biochem/physiol Actions
Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).
storage
Store at +4°C
Properties of NU7026
| Melting point: | 267-269 °C(Solv: methanol (67-56-1); water (7732-18-5)) |
| Boiling point: | 459.9±45.0 °C(Predicted) |
| Density | 1.330 |
| storage temp. | 2-8°C |
| solubility | DMSO: 3 mg/mL at 60 °C, soluble |
| form | solid |
| pka | 0.49±0.20(Predicted) |
| color | tan |
Safety information for NU7026
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P405:Store locked up. |
Computed Descriptors for NU7026
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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