KN-93 Phosphate
- CAS NO.:1188890-41-6
- Empirical Formula: C26H32ClN2O8PS
- Molecular Weight: 599.032641
- MDL number: MFCD03788201
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is KN-93 Phosphate?
Description
KN-93 (phosphate) is a potent and selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII) (Ki = 370 nM), inhibiting both the α- and β-subunits of CaMKII. It does not have significant effects on cAMP-dependent protein kinase, Ca2+/phospholipid-dependent protein kinase, myosin light chain kinase, or Ca2+ phosphodiesterase activity. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 can block voltage-gated potassium (Kv) channels when applied extracellularly, independent of its CaMKII action. More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cells.
The Uses of KN-93 Phosphate
KN 93 Phosphate is a potent and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II.
storage
-20°C
Properties of KN-93 Phosphate
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMF:25.0(Max Conc. mg/mL);41.73(Max Conc. mM) DMSO:76.67(Max Conc. mg/mL);127.98(Max Conc. mM) Water:49.33(Max Conc. mg/mL);82.35(Max Conc. mM) |
form | White to off-white solid. |
Water Solubility | Soluble in water (10mM) |
CAS DataBase Reference | 1188890-41-6 |
Safety information for KN-93 Phosphate
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P363:Wash contaminated clothing before reuse. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for KN-93 Phosphate
New Products
2,2-diethoxyethanethioamide Tubulysin G Tubulysin M 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2H-Pyran, 4-ethynyltetrahydro- 4,4-DIFLUOROPIPERIDINE 2,2-Difluoropropanol (S)-(+)-3-HYDROXYTETRAHYDROFURAN 2,2-Difluoropropylamine hydrochloride 3-Ethynylaniline Hydrochloride (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 5-Nitro-3-(trifluoromethyl)pyridine-2-carbonitrile ? 4-((1-Cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide ? 3-Iodo-4-methyl-n-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide ?(S)-2-((S)-2-Cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile (2S)-3-Methyl-2-(methylamino)-1-butanol (R)-methyl 2-isocyano-3-(tritylthio)propanoate (R)-methyl 2-formamido-3-(tritylthio)propanoate HYDROCORTISONE ACETATE EP IMPURITY E FUSIDIC ACID EP IMPURITY O / FUSIDIC ACID BP IMPURITY O / 16-DEACETYL FUSIDIC ACID SODIUM SALT Montelukast EP Impurity F | Montelukast USP Related Compound ERelated products of tetrahydrofuran
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