KN-62
Synonym(s):(S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester;1-[N,O- bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II;1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II;1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L -tyrosyl]-4-phenylpiperazine;KN-62 - CAS 127191-97-3 - Calbiochem
- CAS NO.:127191-97-3
- Empirical Formula: C38H35N5O6S2
- Molecular Weight: 721.84
- MDL number: MFCD00083180
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is KN-62?
Chemical properties
Yellow Solid
The Uses of KN-62
It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
The Uses of KN-62
A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II
The Uses of KN-62
selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,
What are the applications of Application
KN-62 is a potent and selective inhibitor of CaMKII
Definition
ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.
General Description
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
Biological Activity
Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions
Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.
storage
-20°C (desiccate)
Properties of KN-62
Melting point: | 92-94°C |
Boiling point: | 964.7±75.0 °C(Predicted) |
Density | 1.388 |
storage temp. | -20°C |
solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL |
form | solid |
pka | 4.07±0.13(Predicted) |
color | white |
CAS DataBase Reference | 127191-97-3(CAS DataBase Reference) |
Safety information for KN-62
Computed Descriptors for KN-62
New Products
Tubulysin I Tubulysin C (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Potassium HMDS (1.0 M in THF) CYCLOBUTYLAMINE HYDROCHLORIDE 2H-Pyran, 4-ethynyltetrahydro- 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one (R)-Methanesulfonic acid 3-(3-fluoro-4- morpholin-4-yl- phenyl)-2-oxo- oxazolidin-5-ylmethyl 4-(2-fluoro-4- nitrophenyl) thiomorpholine 1-(2,3-Dihydro- benzofuran-5-yl) -ethanone Latanoprostene Bunod Lubiprostone Magnesium Trisilicate 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid (2R,3S)-2-Azido-3-methylpentanoic acid Methyl (2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoate Quetiapine EP Impurity D Simvastatin Acid Triol Sodium SaltRelated products of tetrahydrofuran
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