Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listKisspeptin 10 (human)

Kisspeptin 10 (human)

Synonym(s):Gene product (112-121) amide, human;KiSS-1;Kisspeptin-10

  • CAS NO.:374675-21-5
  • Empirical Formula: C63H83N17O14
  • Molecular Weight: 1302.44
  • MDL number: MFCD03452696
  • EINECS: 675-121-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-25 20:05:57
Kisspeptin 10 (human) Structural

What is Kisspeptin 10 (human)?

Description

Metastin (45-54) is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.

The Uses of Kisspeptin 10 (human)

Metastin (45-54) is a potent and selective agonist of AXOR12 and hOT7T175.

The Uses of Kisspeptin 10 (human)

Kisspeptin 10 (human) is a powerful and specific activator for AXOR12 and hOT7T175 receptors. The Kisspeptin 10 (human) amide has been utilized in studies involving progesterone release from MA-10 cells and in experiments to induce gonadal differentiation in clownfish.

What are the applications of Application

Metastin (45-54) is a potent and selective agonist of AXOR12 and hOT7T175

General Description

Metastin is also known as kisspeptin 1 (KISS1). It is encoded by KISS1 gene, that is mapped to human chromosome 1q32. Metastin is a tumor suppressor protein, made up of 145 amino acids. The protein fragments contain RFamide motif at the C- terminal end. The encoded protein is expressed in the human hypothalamus, gonads, placenta, liver and pancreas. This novel?peptide?is mainly isolated from the human placenta.

Biological Activity

The study revealed that the down regulation of galactose and up regulation of glycogenic amino acids (GAAs), including L-alanine, L-glutamic acid, L-methionine, L-proline and L-valine, in the kisspeptin-10 group suggests the accelerated carbohydrate metabolism, which indicates a negative energy balance. Moreover, in the kisspeptin-10-treated rats, high levels of GAAs that were possibly derived from protein decomposition might cause a negative nitrogen balance. It was found that increases of ketogenic amino acids such as tyrosine indicate a disturbance in glucose use, which might be induced by kisspeptin-10 in this study. In contrast, cholesterol increased significantly in the rats treated with kisspeptin-10, suggesting disrupted lipid metabolism, which might result from a lipolysis blockade[1].

Biochem/physiol Actions

Kisspeptin 10 (human) is a highly effective natural ligand for the Kisspeptin receptor (KISS1, GPR54). It exhibits strong binding affinity to rat and human KISS1 receptors, with Ki values of 1.59 and 2.33 nM respectively. This peptide inhibits metastasis and invasion in mouse melanomas and triggers gonadotropin release upon intracerebroventricular administration.

Mechanism of action

The kisspeptin (Kp) precursor contains 145 amino acids and can be hydrolyzed into Kp-54, Kp-14, Kp-13 and Kp-10. Kp-10, the shortest subtype with high activity, plays a vital role in many tissues. Kisspeptin 10 inhibited the expression of vascular endothelial growth factor (VEGF) in human umbilical vein endothelial cells, the main inducer of high vascular permeability (VP). Moreover, Kp-10 also promotes follicle maturation, ovulation and progesterone production. Exogenous Kp-10 injection decreased VP and VEGF by enhancing Kiss1r in OHSS rats without affecting ovulation [3].

storage

Store at -20°C

Clinical claims and research

Kisspeptin-10 level is useful in assessing the severity of preeclampsia and can be a novel marker downregulated in pregnant women with preeclampsia, especially in those who also developed impaired uteroplacental perfusion or intrauterine growth restriction[2].

References

[1] Zhang Y, et al. The effects of kisspeptin-10 on serum metabolism and myocardium in rats. PLOS ONE, 2017; 12: e0179164.
[2] Ziyaraa M, et al. Correlation of Kisspeptin-10 level and fetal well-being in preeclamptic patients. Taiwanese Journal of Obstetrics and Gynecology, 2016; 55: 840-846.
[3] Zhai J, et al. Kisspeptin-10 inhibits OHSS by suppressing VEGF secretion. Reproduction, 2017; 154: 355–362.

Properties of Kisspeptin 10 (human)

Density  1.46±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml
form  A crystalline solid
pka 9.96±0.15(Predicted)
color  White to off-white
Water Solubility  Soluble in water at 1mg/ml

Safety information for Kisspeptin 10 (human)

Computed Descriptors for Kisspeptin 10 (human)

InChIKey RITKWYDZSSQNJI-INXYWQKQSA-N

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.