CYCLIC-PIFITHRIN-ALPHA
Synonym(s):2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ;Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem
- CAS NO.：60477-34-1
- Empirical Formula: C16H16N2S
- Molecular Weight: 268.38
- MDL number: MFCD02108837
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:07
What is CYCLIC-PIFITHRIN-ALPHA?
Definition
ChEBI: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole is a member of imidazoles.
General Description
A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
Biochem/physiol Actions
Cell permeable: yes
Properties of CYCLIC-PIFITHRIN-ALPHA
| Melting point: | 266.4-267.3 °C(lit.) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO: 20 mg/mL |
| form | White solid |
| pka | 6.75±0.20(Predicted) |
Safety information for CYCLIC-PIFITHRIN-ALPHA
Computed Descriptors for CYCLIC-PIFITHRIN-ALPHA
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