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HomeProduct name listCYCLIC-PIFITHRIN-ALPHA

CYCLIC-PIFITHRIN-ALPHA

Synonym(s):2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ;Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem

CYCLIC-PIFITHRIN-ALPHA Structural

What is CYCLIC-PIFITHRIN-ALPHA?

Definition

ChEBI: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole is a member of imidazoles.

General Description

A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.

Biochem/physiol Actions

Cell permeable: yes

Properties of CYCLIC-PIFITHRIN-ALPHA

Melting point: 266.4-267.3 °C(lit.)
Density  1.30±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  DMSO: 20 mg/mL
form  White solid
pka 6.75±0.20(Predicted)

Safety information for CYCLIC-PIFITHRIN-ALPHA

Computed Descriptors for CYCLIC-PIFITHRIN-ALPHA

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