Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listCYCLIC-PIFITHRIN-ALPHA

CYCLIC-PIFITHRIN-ALPHA

Synonym(s):2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ;Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem

CYCLIC-PIFITHRIN-ALPHA Structural

What is CYCLIC-PIFITHRIN-ALPHA?

Definition

ChEBI: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole is a member of imidazoles.

General Description

A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.

Biochem/physiol Actions

Cell permeable: yes

Properties of CYCLIC-PIFITHRIN-ALPHA

Melting point: 266.4-267.3 °C(lit.)
Density  1.30±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  DMSO: 20 mg/mL
form  White solid
pka 6.75±0.20(Predicted)

Safety information for CYCLIC-PIFITHRIN-ALPHA

Computed Descriptors for CYCLIC-PIFITHRIN-ALPHA

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.