FHPI HCL

Synonym(s):4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate;4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride;4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate;SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem

CAS NO.：350228-36-3
Empirical Formula: C20H15ClFN3O
Molecular Weight: 367.8
MDL number: MFCD01862621
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is FHPI HCL?

The Uses of FHPI HCL

The water soluble form of SB 202190, a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in high er levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat.

The Uses of FHPI HCL

The water soluble form of SB 202190, a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in higher levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat.

What are the applications of Application

SB202190 hydrochloride is an inhibitor of the isoforms p38α and p38&beta

General Description

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).

Biochem/physiol Actions

SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines.

Properties of FHPI HCL

storage temp.	-20°C
solubility	DMSO: ≥12mg/mL
form	solid
color	white to beige

Safety information for FHPI HCL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.