JNJ-7706621
Synonym(s):4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, JNJ-7706621, Aurora Kinase Inhibitor I;Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem
- CAS NO.:443797-96-4
- Empirical Formula: C15H12F2N6O3S
- Molecular Weight: 394.36
- MDL number: MFCD11100270
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:44:47
What is JNJ-7706621?
Description
JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDKs) and Aurora kinases. It potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC50s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively). It shows selectivity for these enzymes over a panel of other receptors and kinases, although it exhibits submicromolar inhibition of VEGF and FGF receptors, as well as GSK3β. JNJ-7706621 blocks the growth of a large variety of cancer cell lines (IC50 values range from 112 to 514 nM), with lower potency against normal cells (IC50 values between 3.67 and 5.42 μM). It induces the regression of A375 melanoma human tumor xenografts in mice. JNJ-7706621 is a substrate for the ATP-binding cassette transporter G2, also known as breast cancer resistance protein.
The Uses of JNJ-7706621
JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing''s sarcoma.
What are the applications of Application
Aurora Kinase/Cdk Inhibitor is (JNJ-7706621) a cell-permeable, reversible, ATP-competitive kinase inhibitor
Definition
ChEBI: 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide is a sulfonamide.
Properties of JNJ-7706621
Melting point: | 149-155℃ |
Boiling point: | 676.6±65.0 °C(Predicted) |
Density | 1.71 |
storage temp. | +2C to +8C |
solubility | Soluble in DMSO at 15mg/ml |
form | White solid |
pka | 9.80±0.12(Predicted) |
color | White to off-white |
Sensitive | Light Sensitive |
Safety information for JNJ-7706621
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for JNJ-7706621
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