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CCT129202

CCT129202 Structural

What is CCT129202?

Biological Activity

CCT129202 is an ATP-competitive pan-Aurora inhibitor with IC50s of 0.042 μM, 0.198 μM and 0.227 μM for Aurora A, Aurora B and Aurora C, respectively, and has a weaker effect on FGFR3, GSK3β, PDGFRβ, etc.

in vivo

CCT129202 at a dose of 100 mg/kg subcutaneously injected HCT116 colon xenografts in athymic mice, after 30 minutes, caused a ~50% decrease in histone H3 phosphorylation, and after 9 days of treatment, significantly inhibited tumor growth, compared with the control group , inhibited by 57.7%.

Properties of CCT129202

Density  1.427
storage temp.  Store at -20°C
solubility  DMSO : 1 mg/mL (2.01 mM; Need ultrasonic)
form  Powder
pka 9.26±0.50(Predicted)
color  Light yellow to yellow

Safety information for CCT129202

Computed Descriptors for CCT129202

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