CCT129202
- CAS NO.：942947-93-5
- Empirical Formula: C23H25ClN8OS
- Molecular Weight: 497.02
- MDL number: MFCD18074522
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:44:47
What is CCT129202?
Biological Activity
CCT129202 is an ATP-competitive pan-Aurora inhibitor with IC50s of 0.042 μM, 0.198 μM and 0.227 μM for Aurora A, Aurora B and Aurora C, respectively, and has a weaker effect on FGFR3, GSK3β, PDGFRβ, etc.
in vivo
CCT129202 at a dose of 100 mg/kg subcutaneously injected HCT116 colon xenografts in athymic mice, after 30 minutes, caused a ~50% decrease in histone H3 phosphorylation, and after 9 days of treatment, significantly inhibited tumor growth, compared with the control group , inhibited by 57.7%.
Properties of CCT129202
| Density | 1.427 |
| storage temp. | Store at -20°C |
| solubility | DMSO : 1 mg/mL (2.01 mM; Need ultrasonic) |
| form | Powder |
| pka | 9.26±0.50(Predicted) |
| color | Light yellow to yellow |
Safety information for CCT129202
Computed Descriptors for CCT129202
New Products
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