ISOXICAM
Synonym(s):4-Hydroxy-2-methyl-N-5-methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
- CAS NO.:34552-84-6
- Empirical Formula: C14H13N3O5S
- Molecular Weight: 335.34
- MDL number: MFCD00079374
- EINECS: 252-084-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:17
What is ISOXICAM?
Description
Isoxicam is a non-steroidal antiinflammatory agent useful in the treatment of various forms of rheumatoid arthritis, osteoarthritis and musculoskeletal disorders. It is about one-tenth as potent as its structural relative sudoxicam; its similar long T1/2 (>30 hrs.) allows once-daily dosing.
Originator
Warner-Lambert (USA)
The Uses of ISOXICAM
Isoxicam is used for the same indications as piroxicam. Synonyms for isoxicam are floxicam and maxicam.
The Uses of ISOXICAM
antiseborrheic
The Uses of ISOXICAM
Isoxicam is a potent, orally active, nonsteroidal anti-inflammatory drug.
Background
Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
What are the applications of Application
Isoxicam is a nonsteroidal anti-inflammatory
Definition
ChEBI: A monocarboxylic acid amide that is piroxicam in which the pyrid-2-yl group is replaced by a 5-methyl-1,2-oxazol-3-yl group. A non-steroidal anti-inflammatory drug, it was withdrawn from the market in the 1980s following its association with cases of Steve s-Johnson syndrome.
Manufacturing Process
A mixture of 40.5 g (0.15 mol) of 3-carbethoxy-4-hydroxy-2-methyl-2H-1,2- benzothiazine 1,1-dioxide, 20.6 g (0.21 mol) of 3-amino-5-methylisoxazole, and 2,500 ml of xylene was refluxed for 24 hours in a Soxhlet apparatus, the thimble of which contained 60 g of Linde type 4A molecular sieve. The mixture was cooled to 25°C and the resulting crystalline precipitate was collected and washed with ether to give 44 g of crude product. Recrystallization from 1,600 ml of 1,4-dioxan gave 34.7 g of material, MP 265°C to 271°C dec.
brand name
Maxicam (Parke-Davis);Floxicam;PACYL.
Therapeutic Function
Antiinflammatory
World Health Organization (WHO)
Isoxicam, a nonsteroidal anti-inflammatory agent, was introduced in 1983 for the treatment of rheumatic disorders. By 1985 its use had been associated with serious adverse effects, including four deaths from rare skin reactions. This led to its withdrawal in France followed immediately by the voluntary suspension of marketing worldwide by the major manufacturer.
Clinical Use
Isoxicam is a nonsteroidal anti-inflammatory drug withdrawn from the market as a consequence of reports of fatal skin reaction.
Synthesis
Isoxicam, 1,1-dioxide 4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H-1,2- benzothiazine-3-carboxamide (3.2.80), is synthesized analogous to piroxicam, using amidation of 1,1-dioxide 3-methoxycarbonyl-3,4-dihydro-2-H-1,2-benzothiazine-4-one (3.2.78) in the last stage with 3-amino-5-methylisoxazole, instead of 2-aminopyridine [127¨C130].
Metabolism
Not Available
Properties of ISOXICAM
Melting point: | 265-271℃ |
Density | 1.588 |
storage temp. | -20°C Freezer |
solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated, Soni |
form | neat |
pka | 4.50±1.00(Predicted) |
form | Solid |
color | White to Pale Beige |
Safety information for ISOXICAM
Computed Descriptors for ISOXICAM
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin G Tubulysin B Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-Aminocyclobutanone hydrochloride tetrahydro-4-methyl-2H-pyran 2H-Pyran, 4-ethynyltetrahydro- 1-(1,1-Difluoroethyl)-2-fluorobenzene 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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