N-methylisatoic anhydride
Synonym(s):1-Methyl-1H -benzo[d ][1,3]oxazine-2,4-dione;1-Methyl-4H -3,1-benzoxazine-2,4(1H )dione
- CAS NO.：10328-92-4
- Empirical Formula: C9H7NO3
- Molecular Weight: 177.16
- MDL number: MFCD00006815
- EINECS: 233-714-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:57
What is N-methylisatoic anhydride?
Chemical properties
brownish chunks
The Uses of N-methylisatoic anhydride
N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs, and is widely used for resolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology.
Definition
ChEBI: N-methylisatoic anhydride is a 3,1-benzoxazin-1,4-dione having an N-methyl substituent.
What are the applications of Application
N-Methylisatoic anhydride was first condensed with ethanolamine to give N-(2-hydroxyethyl)-2-methylaminobenzamide. Cyclization of the latter with ethyl pyruvate gave quinazoline derivatives which, upon hydrolysis and dehydrative cyclization with l-methyl-2-chloropyridinium iodide, afforded the l,4-oxazines[3,4-]quinazoline.
Properties of N-methylisatoic anhydride
| Melting point: | 165 °C (dec.)(lit.) |
| Boiling point: | 309.06°C (rough estimate) |
| Density | 1.3312 (rough estimate) |
| vapor density | 6.1 (vs air) |
| refractive index | 1.5200 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | -2.24±0.20(Predicted) |
| color | White to yellow |
| Sensitive | Moisture Sensitive |
| CAS DataBase Reference | 10328-92-4(CAS DataBase Reference) |
| EPA Substance Registry System | 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl- (10328-92-4) |
Safety information for N-methylisatoic anhydride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-methylisatoic anhydride
N-methylisatoic anhydride manufacturer
ALS INDIA LIFE SCIENCES
1Y
Phone:+91-8977036379
Whatsapp: +91 8008166674
product: 10328-92-4 N-methyl-isatoic anhydride 98%
New Products
4-Fluorophenylacetic acid 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate (6-METHYL-[1,3]DITHIOLO[4,5-b]QUINOXALIN-2-ONE INDAZOLE-3-CARBOXYLIC ACID 4-IODO BENZOIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![1-ISOPROPYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE](https://img.chemicalbook.in/CAS/GIF/57384-39-1.gif)
![5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE](https://img.chemicalbook.in/CAS/GIF/40707-01-5.gif)
You may like
-
10328-92-4 N-methyl-isatoic anhydride 98%View Details
10328-92-4 -
N-Methylisatoic Anhydride CAS 10328-92-4View Details
10328-92-4 -
N-Methylisatoic anhydride CAS 10328-92-4View Details
10328-92-4 -
N-Methylisatoic anhydride 98% (GC) CAS 10328-92-4View Details
10328-92-4 -
N-Methylisatoic anhydride 95.00% CAS 10328-92-4View Details
10328-92-4 -
1975-50-4 98%View Details
1975-50-4 -
14714-50-2 (2-Hydroxyphenyl)acetonitrile 98+View Details
14714-50-2 -
118753-70-1 98+View Details
118753-70-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.