N-methylisatoic anhydride
Synonym(s):1-Methyl-1H -benzo[d ][1,3]oxazine-2,4-dione;1-Methyl-4H -3,1-benzoxazine-2,4(1H )dione
- CAS NO.：10328-92-4
- Empirical Formula: C9H7NO3
- Molecular Weight: 177.16
- MDL number: MFCD00006815
- EINECS: 233-714-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is N-methylisatoic anhydride?
Chemical properties
brownish chunks
The Uses of N-methylisatoic anhydride
N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs, and is widely used for resolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology.
Definition
ChEBI: N-methylisatoic anhydride is a 3,1-benzoxazin-1,4-dione having an N-methyl substituent.
What are the applications of Application
N-Methylisatoic anhydride was first condensed with ethanolamine to give N-(2-hydroxyethyl)-2-methylaminobenzamide. Cyclization of the latter with ethyl pyruvate gave quinazoline derivatives which, upon hydrolysis and dehydrative cyclization with l-methyl-2-chloropyridinium iodide, afforded the l,4-oxazines[3,4-]quinazoline.
Properties of N-methylisatoic anhydride
| Melting point: | 165 °C (dec.)(lit.) |
| Boiling point: | 309.06°C (rough estimate) |
| Density | 1.3312 (rough estimate) |
| vapor density | 6.1 (vs air) |
| refractive index | 1.5200 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | -2.24±0.20(Predicted) |
| color | White to yellow |
| Sensitive | Moisture Sensitive |
| CAS DataBase Reference | 10328-92-4(CAS DataBase Reference) |
| EPA Substance Registry System | 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl- (10328-92-4) |
Safety information for N-methylisatoic anhydride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-methylisatoic anhydride
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product: 10328-92-4 N-methyl-isatoic anhydride 98%
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