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HomeProduct name listIndole-6-carboxylic acid

Indole-6-carboxylic acid

Synonym(s):6-Carboxyindole

  • CAS NO.:1670-82-2
  • Empirical Formula: C9H7NO2
  • Molecular Weight: 161.16
  • MDL number: MFCD02258929
  • EINECS: 605-464-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-24 19:19:26
Indole-6-carboxylic acid Structural

What is Indole-6-carboxylic acid?

Chemical properties

yellow-beige to orange-brown powder

The Uses of Indole-6-carboxylic acid

• ;Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase1• ;Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors2• ;Reactant for preparation of amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway3• ;Reactant for preparation of piperazine-bisamide analogs as human growth hormone secretagogue receptor antagonists for treatment of obesity4• ;Reactant for preparation of pyridinyl carboxylates via esterification with chlorohyd

The Uses of Indole-6-carboxylic acid

Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase ? Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors ? Reactant for preparation of amide conju

The Uses of Indole-6-carboxylic acid

  • Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase
  • Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors
  • Reactant for preparation of amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway
  • Reactant for preparation of piperazine-bisamide analogs as human growth hormone secretagogue receptor antagonists for treatment of obesity
  • Reactant for preparation of pyridinyl carboxylates via esterification with chlorohydroxypyridine as SARS-CoV 3CL proinhibitors
  • Reactant for preparation of (indolecarbonyl)-D-phenylglycinamide amides as factor Xa inhibitors

Synthesis Reference(s)

Journal of Medicinal Chemistry, 35, p. 2419, 1992 DOI: 10.1021/jm00091a010

Properties of Indole-6-carboxylic acid

Melting point: 249-253 °C(lit.)
Boiling point: 287.44°C (rough estimate)
Density  1.2480 (rough estimate)
refractive index  1.5050 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
pka 4.44±0.30(Predicted)
form  Powder
color  Yellow-beige to orange-brown
BRN  123991
CAS DataBase Reference 1670-82-2(CAS DataBase Reference)

Safety information for Indole-6-carboxylic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Indole-6-carboxylic acid

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