Indole-5-carboxylic acid
Synonym(s):5-Carboxyindole
- CAS NO.:1670-81-1
- Empirical Formula: C9H7NO2
- Molecular Weight: 161.16
- MDL number: MFCD00005678
- EINECS: 216-799-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-04 15:29:52
What is Indole-5-carboxylic acid?
Chemical properties
light beige to yellow powder
The Uses of Indole-5-carboxylic acid
Indole-5-carboxylic acid is the suitable reagent used to study the intermolecular excited state proton transfer in indole-2-carboxylic acid and indole-5-carboxylic acid in various solvents in acidic, basic, and neutral media by steady state and time resolved fluorescence spectroscopy. It may be used in the electrochemical synthesis of poly(indole-5-carboxylic acid) (PICA) films. Also used as reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, as potential anticancer immunomodulators, synthesis of indirubin derivatives and amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway.
The Uses of Indole-5-carboxylic acid
Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, as potential anticancer immunomodulators 1 Reactant for preparation of indolyl-quinolines via metal- and solvent-free autoxidative coupling reaction 2 Reactant for preparation of anthranilic acids using bromamine-B oxidant and palladium chloride catalyst 3 Reactant for synthesis of indirubin derivatives 4 Reactant for preparation of amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway 5 Reactant for preparation of piperazine-bisamide analogs as human growth hormone secretagogue receptor antagonists for treatment of obesity.
The Uses of Indole-5-carboxylic acid
Indole-5-carboxylic acid is the suitable reagent used to study the intramolecular excited state proton transfer in indole-2-carboxylic acid and indole-5-carboxylic acid in various solvents in acidic, basic, and neutral media by steady state and time resolved fluorescence spectroscopy. It may be used in the electrochemical synthesis of poly(indole-5-carboxylic acid) (PICA) films.
Definition
ChEBI: Indole-5-carboxylic acid is an indolecarboxylic acid in which the carboxy group is the only substituent and is located at position 5. It has a role as a plant metabolite.
General Description
Indole-5-carboxylic acid is an indole derivative. On electropolymerization, it affords electroactive polymer film of poly(indole-5-carboxylic-acid). Different concentrations of indole-5-carboxylic acid in sulfuric acid solution has been investigated for the preventive action against mild steel corrosion. On electropolymerization it affords a trimeric product. Characterization studies of the trimeric product by 1H NMR and various one- and two-dimensional NMR techniques have been reported.
Properties of Indole-5-carboxylic acid
Melting point: | 211-213 °C (lit.) |
Boiling point: | 287.44°C (rough estimate) |
Density | 1.2480 (rough estimate) |
refractive index | 1.5050 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Soluble in ethanol (50 mg/ml), dimethyl sulfoxide and methanol. |
pka | 4.40±0.30(Predicted) |
form | Powder |
color | Light beige to yellow |
BRN | 124391 |
CAS DataBase Reference | 1670-81-1(CAS DataBase Reference) |
Safety information for Indole-5-carboxylic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Indole-5-carboxylic acid
InChIKey | IENZCGNHSIMFJE-UHFFFAOYSA-N |
Abamectin manufacturer
Sunlight Active Drug Ingredients Pvt ltd
Moraya GlobaL Private Limited
New Products
Tubulysin A (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin M 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- tetrahydro-4-methyl-2H-pyran 3-N-BOC-(S)-AMINO BUTYRONITRILE 2,2-Difluoropropanol Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell Calcium Sodium Phosphosilicate IH (+/-)-2, 6-Diamino-4,5,6,7 -tetrahydro Benzothiazole (R)-1-Aminoindan Hydrochloride Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
1670-81-1 Indole-5-carboxylic acid 98%View Details
1670-81-1 -
1670-81-1 99%View Details
1670-81-1 -
1H-Indole-5-carboxylic acid 1670-81-1 98%View Details
1670-81-1 -
Indole-5-carboxylic acid 98% CAS 1670-81-1View Details
1670-81-1 -
Indole-5-carboxylic Acid CAS 1670-81-1View Details
1670-81-1 -
Indole-5-carboxylic acid >98% (HPLC) CAS 1670-81-1View Details
1670-81-1 -
Indole-5-carboxylic acid, 95% CAS 1670-81-1View Details
1670-81-1 -
Indole-5-Carboxyllic Acid CAS 1670-81-1View Details
1670-81-1