illudin S
- CAS NO.:1149-99-1
- Empirical Formula: C15H20O4
- Molecular Weight: 264.32
- MDL number: MFCD00870487
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 13:32:20
What is illudin S?
Description
Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.
The Uses of illudin S
Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.
The Uses of illudin S
Illudin S is a potent antitumor sesquiterpene.
What are the applications of Application
Illudin S is a potent antitumor sesquiterpene
Definition
ChEBI: Illudin S is a sesquiterpenoid.
Properties of illudin S
Melting point: | 124-126℃ |
Boiling point: | 327.55°C (rough estimate) |
Density | 1.0583 (rough estimate) |
refractive index | 1.4300 (estimate) |
storage temp. | -20°C, Inert atmosphere |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | A light yellow solid |
pka | 12.50±0.70(Predicted) |
color | Off-white to yellow |
Safety information for illudin S
Computed Descriptors for illudin S
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