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HomeProduct name listilludin S

illudin S

illudin S Structural

What is illudin S?

Description

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.

The Uses of illudin S

Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.

The Uses of illudin S

Illudin S is a potent antitumor sesquiterpene.

What are the applications of Application

Illudin S is a potent antitumor sesquiterpene

Definition

ChEBI: Illudin S is a sesquiterpenoid.

Properties of illudin S

Melting point: 124-126℃
Boiling point: 327.55°C (rough estimate)
Density  1.0583 (rough estimate)
refractive index  1.4300 (estimate)
storage temp.  -20°C, Inert atmosphere
solubility  DMSO (Slightly), Methanol (Slightly)
form  A light yellow solid
pka 12.50±0.70(Predicted)
color  Off-white to yellow

Safety information for illudin S

Computed Descriptors for illudin S

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