Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listilludin S

illudin S

illudin S Structural

What is illudin S?

Description

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.

The Uses of illudin S

Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.

The Uses of illudin S

Illudin S is a potent antitumor sesquiterpene.

What are the applications of Application

Illudin S is a potent antitumor sesquiterpene

Definition

ChEBI: Illudin S is a sesquiterpenoid.

Properties of illudin S

Melting point: 124-126℃
Boiling point: 327.55°C (rough estimate)
Density  1.0583 (rough estimate)
refractive index  1.4300 (estimate)
storage temp.  -20°C, Inert atmosphere
solubility  DMSO (Slightly), Methanol (Slightly)
form  A light yellow solid
pka 12.50±0.70(Predicted)
color  Off-white to yellow

Safety information for illudin S

Computed Descriptors for illudin S

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.