IDRA 21
Synonym(s):7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
- CAS NO.：22503-72-6
- Empirical Formula: C8H9ClN2O2S
- Molecular Weight: 232.69
- MDL number: MFCD00270874
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-19 18:29:52
What is IDRA 21?
Chemical properties
white to off-white crystalline powder
The Uses of IDRA 21
IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.
The Uses of IDRA 21
IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).
What are the applications of Application
IDRA 21 is an analog of cyclothiazide that Inhibits AMPA receptor desensitization
Definition
ChEBI: 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide is a benzothiadiazine.
Biological Activity
Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).
storage
Room temperature
Properties of IDRA 21
| Melting point: | 209 °C(Solv: acetic acid (64-19-7)) |
| Boiling point: | 405.1±55.0 °C(Predicted) |
| Density | 1.394±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 9.78±0.40(Predicted) |
| color | Off-White to Pale Yellow |
Safety information for IDRA 21
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for IDRA 21
| InChIKey | VZRNTCHTJRLTMU-UHFFFAOYSA-N |
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