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HomeProduct name listIDRA 21

IDRA 21

Synonym(s):7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

  • CAS NO.:22503-72-6
  • Empirical Formula: C8H9ClN2O2S
  • Molecular Weight: 232.69
  • MDL number: MFCD00270874
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-29 13:08:54
IDRA 21 Structural

What is IDRA 21?

Chemical properties

white to off-white crystalline powder

The Uses of IDRA 21

IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.

The Uses of IDRA 21

IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).

What are the applications of Application

IDRA 21 is an analog of cyclothiazide that Inhibits AMPA receptor desensitization

Definition

ChEBI: 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide is a benzothiadiazine.

Biological Activity

Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).

storage

Room temperature

Properties of IDRA 21

Melting point: 209 °C(Solv: acetic acid (64-19-7))
Boiling point: 405.1±55.0 °C(Predicted)
Density  1.394±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  DMSO (Slightly), Methanol (Slightly, Sonicated)
form  Solid
pka 9.78±0.40(Predicted)
color  Off-White to Pale Yellow

Safety information for IDRA 21

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for IDRA 21

InChIKey VZRNTCHTJRLTMU-UHFFFAOYSA-N

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