Hydroxy-PEG3-t-butylester
- CAS NO.：133803-81-3
- Empirical Formula: C11H22O5
- Molecular Weight: 234.29
- MDL number: MFCD20926380
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is Hydroxy-PEG3-t-butylester?
Description
Hydroxy-PEG2-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
The Uses of Hydroxy-PEG3-t-butylester
Hydroxy-PEG2-(CH2)2-Boc is an ADC linker for the synthesis of antibody drug conjugates (ADC), Hydroxy-PEG2-(CH2)2-Boc is derived from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc can also be used as a PROTAC linker for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of Hydroxy-PEG3-t-butylester
| Boiling point: | 321.8±22.0 °C(Predicted) |
| Density | 1.046±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO |
| pka | 14.36±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
Safety information for Hydroxy-PEG3-t-butylester
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Hydroxy-PEG3-t-butylester
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