TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
Synonym(s):tert-Butyl-1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate;HO-PEG4-CO-OtBu
- CAS NO.：186020-66-6
- Empirical Formula: C13H26O6
- Molecular Weight: 278.34
- MDL number: MFCD03791106
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-?
Description
Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Biological Activity
Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
| Boiling point: | 365.8±27.0 °C(Predicted) |
| Density | 1.052 g/mL at 20 °C (lit.) |
| refractive index | n |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO |
| form | clear liquid |
| pka | 14.36±0.10(Predicted) |
| color | Colorless to Light yellow to Light orange |
| BRN | 7638988 |
| CAS DataBase Reference | 186020-66-6 |
Safety information for TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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