TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

Synonym(s):tert-Butyl-1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate;HO-PEG4-CO-OtBu

CAS NO.：186020-66-6
Empirical Formula: C13H26O6
Molecular Weight: 278.34
MDL number: MFCD03791106
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Structural

What is TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-?

Description

Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Biological Activity

Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Properties of TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

Boiling point:	365.8±27.0 °C(Predicted)
Density	1.052 g/mL at 20 °C (lit.)
refractive index	n20/D 1.446
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in DMSO
form	clear liquid
pka	14.36±0.10(Predicted)
color	Colorless to Light yellow to Light orange
BRN	7638988
CAS DataBase Reference	186020-66-6

Safety information for TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.