Hydroxy-PEG4-t-butyl ester
Synonym(s):tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate;HO-PEG5-CO-OtBu
- CAS NO.:518044-32-1
- Empirical Formula: C15H30O7
- Molecular Weight: 322.39
- MDL number: MFCD11041117
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-25 20:41:16
What is Hydroxy-PEG4-t-butyl ester?
Description
Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
The Uses of Hydroxy-PEG4-t-butyl ester
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of Hydroxy-PEG4-t-butyl ester
Boiling point: | 406.8±35.0 °C(Predicted) |
Density | 1.04746 g/mL |
refractive index | n/D 1.4492 |
storage temp. | 2-8°C |
solubility | Soluble in Water, DCM |
pka | 14.36±0.10(Predicted) |
form | liquid |
color | Colorless to Light yellow to Light orange |
Safety information for Hydroxy-PEG4-t-butyl ester
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Hydroxy-PEG4-t-butyl ester
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