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HomeProduct name listHydroxy-PEG4-t-butyl ester

Hydroxy-PEG4-t-butyl ester

Synonym(s):tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate;HO-PEG5-CO-OtBu

Hydroxy-PEG4-t-butyl ester Structural

What is Hydroxy-PEG4-t-butyl ester?

Description

Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

The Uses of Hydroxy-PEG4-t-butyl ester

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Properties of Hydroxy-PEG4-t-butyl ester

Boiling point: 406.8±35.0 °C(Predicted)
Density  1.04746 g/mL
refractive index  n/D 1.4492
storage temp.  2-8°C
solubility  Soluble in Water, DCM
pka 14.36±0.10(Predicted)
form  liquid
color  Colorless to Light yellow to Light orange

Safety information for Hydroxy-PEG4-t-butyl ester

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Hydroxy-PEG4-t-butyl ester

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