HO-PEG5-tBu
- CAS NO.:850090-09-4
- Empirical Formula: C17H34O8
- Molecular Weight: 366.45
- MDL number: MFCD20926402
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:00
What is HO-PEG5-tBu?
Description
Hydroxy-PEG5-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
The Uses of HO-PEG5-tBu
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of HO-PEG5-tBu
Boiling point: | 445.4±40.0 °C(Predicted) |
Density | 1.071 |
refractive index | n/D 1.448 |
storage temp. | -20°C |
form | liquid |
pka | 14.36±0.10(Predicted) |
color | Colorless to light yellow |
Safety information for HO-PEG5-tBu
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for HO-PEG5-tBu
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