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HomeProduct name listHoechst 33342

Hoechst 33342

Synonym(s):;2′-(4-Ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5′-bi-1H-benzimidazole trihydrochloride;bisBenzimide;

  • CAS NO.:23491-52-3
  • Empirical Formula: C27H28N6O
  • Molecular Weight: 452.55
  • MDL number: MFCD00166996
  • EINECS: 245-691-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:42
Hoechst 33342 Structural

What is Hoechst 33342?

Chemical properties

yellow powder

The Uses of Hoechst 33342

Hoechst 33342 is useful for staining DNA, chromosomes and nuclei. May be used for fluorescence microscopy or flow cytometry. Suitable for vital DNA staining of a variety of cell types and as a probe of membrane permeability in mammalian cells.

The Uses of Hoechst 33342

Hoechst 33342 is an A:T-specific DNA minor groove ligand that is a widely used fluorochrome for visualizing cellular DNA. Excitation of the dye occurs around 350 nm with an emission maxima around 461 nm. Hoechst-33342, unlike other Hoechst dyes, is more lipophillic due to an additional ethyl group. The compound has been observed to displace several known DNA intercalators. Adriamycin has been shown to disrupt the DNA dye update. The compound can be used in sorting living cells based on DNA content by FACS, in the visualization of chromatin distribution in living cells, to detect BrdU incorporation into cells, the visualization of fixed cells by microscopy, and to study the initial stages of apoptosis and cell-cycle distribution. In addition to Hoechst-33342''s fluorescent capability, the

What are the applications of Application

Hoechst 33342, UltraPure grade is a lipophilic fluorescent stain for DNA labeling

What are the applications of Application

Hoechst 33342 trihydrochloride is an A:T-specific DNA minor groove ligand used for visualizing cellular DNA

Definition

ChEBI: 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole is a bibenzimidazole and a N-methylpiperazine. It has a role as a fluorochrome. It is functionally related to a pibenzimol.

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx.

Properties of Hoechst 33342

Boiling point: 725.9±70.0 °C(Predicted)
Density  1.274±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  H2O: soluble20mg/mL
form  Yellow solid
pka 10.97±0.10(Predicted)
color  Brown to breen
Water Solubility  Water : 1 mg/mL (2.21 mM; ultrasonic and warming and heat to 80°C)
BRN  1234011
CAS DataBase Reference 23491-52-3(CAS DataBase Reference)

Safety information for Hoechst 33342

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H341:Germ cell mutagenicity
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Hoechst 33342

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