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HomeProduct name listHEXAMETHONIUM CHLORIDE

HEXAMETHONIUM CHLORIDE

Synonym(s):Hexamethonium dichloride;N,N,N,N′,N′,N′-Hexamethyl-1,6-hexanediaminium dichloride;N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dichloride

  • CAS NO.:60-25-3
  • Empirical Formula: C12H30Cl2N2
  • Molecular Weight: 273.29
  • MDL number: MFCD00031563
  • EINECS: 200-465-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
HEXAMETHONIUM CHLORIDE Structural

What is HEXAMETHONIUM CHLORIDE?

Chemical properties

White, crystalline, hygroscopic powder; faint odor. Very soluble in water; soluble in alcohol, methanol, and n-propanol; insoluble in chloroform and ether. Available commercially as unhydrated form or as dihydrate.

The Uses of HEXAMETHONIUM CHLORIDE

Hexamethonium Chloride is a ganglionic nicotinic receptor blocker.

The Uses of HEXAMETHONIUM CHLORIDE

Medicine (antihypertensive).

The Uses of HEXAMETHONIUM CHLORIDE

Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons.

What are the applications of Application

Hexamethonium chloride is A preferential nicotinic receptor blocker.

General Description

Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction.

Biochem/physiol Actions

Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR.

Properties of HEXAMETHONIUM CHLORIDE

Melting point: 292°C(dec.)(lit.)
Boiling point: 423.36°C (rough estimate)
Density  1.0558 (rough estimate)
refractive index  1.6400 (estimate)
solubility  H2O: soluble
form  solid (hygroscopic)
color  white
Water Solubility  almost transparency
BRN  3714806
CAS DataBase Reference 60-25-3
EPA Substance Registry System 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dichloride (60-25-3)

Safety information for HEXAMETHONIUM CHLORIDE

Computed Descriptors for HEXAMETHONIUM CHLORIDE

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