HARMALINE
Synonym(s):1-Methyl-7-methoxy-3,4-dihydro-β-carboline;3,4-Dihydroharmine;4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido[3,4-b]indole;Dihydroharmine;Harmalol methyl ether
- CAS NO.：304-21-2
- Empirical Formula: C13H14N2O
- Molecular Weight: 214.26
- MDL number: MFCD00004955
- EINECS: 206-152-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:32
What is HARMALINE?
The Uses of HARMALINE
CNS stimulant, antiparkinsonian agent
The Uses of HARMALINE
CNS stimulant; may act through NMDA receptors. Reversible inhibitor of MAO-A
Definition
ChEBI: A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.
Synthesis Reference(s)
Canadian Journal of Chemistry, 37, p. 1851, 1959 DOI: 10.1139/v59-272
Purification Methods
Recrystallise harmaline from MeOH and sublime it at high vacuum. It has UV in MeOH a
Properties of HARMALINE
| Melting point: | 232-234 °C(lit.) |
| Boiling point: | 354.4°C (rough estimate) |
| alpha | ±0° |
| Density | 1.0850 (rough estimate) |
| refractive index | 1.6450 (estimate) |
| solubility | DMF: 1.4 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 0.25 mg/ml; Ethanol: 0.5 mg/ml |
| Water Solubility | Slightly soluble in water |
| form | powder |
| pka | 4.2(at 25℃) |
| color | Light orange to Yellow to Green |
| Merck | 14,4613 |
| BRN | 207310 |
| CAS DataBase Reference | 304-21-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Harmaline(304-21-2) |
| EPA Substance Registry System | 3H-Pyrido[3,4-b]indole, 4,9-dihydro-7-methoxy-1-methyl- (304-21-2) |
Safety information for HARMALINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H371:Specific target organ toxicity, single exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P405:Store locked up. |
Computed Descriptors for HARMALINE
HARMALINE manufacturer
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