Guanosine-5'-diphosphate disodium salt
Synonym(s):5′-GDP-Na2
- CAS NO.：7415-69-2
- Empirical Formula: C10H16N5NaO11P2
- Molecular Weight: 467.2
- MDL number: MFCD00066538
- EINECS: 231-026-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Guanosine-5'-diphosphate disodium salt?
The Uses of Guanosine-5'-diphosphate disodium salt
Guanosine-5'-diphosphate disodium salt is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors. It is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.
General Description
Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.
Biochem/physiol Actions
Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).
Properties of Guanosine-5'-diphosphate disodium salt
| Melting point: | >280°C (dec.) |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | Powder |
| color | White |
| Water Solubility | Soluble in water |
| Stability: | Hygroscopic |
Safety information for Guanosine-5'-diphosphate disodium salt
Computed Descriptors for Guanosine-5'-diphosphate disodium salt
| InChIKey | PVMPTWQLNDHIEV-NGPBCCOENA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C(NC(N)=NC1=2)=O)O.[NaH] |&1:1,2,3,15,r| |
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