GSK-3BETA INHIBITOR XII
Synonym(s):3-[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy]phenol
- CAS NO.:601514-19-6
- Empirical Formula: C18H14N4O2
- Molecular Weight: 318.33
- MDL number: MFCD09037535
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 15:28:16
What is GSK-3BETA INHIBITOR XII?
The Uses of GSK-3BETA INHIBITOR XII
Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.
The Uses of GSK-3BETA INHIBITOR XII
TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.
What are the applications of Application
GSK-3β Inhibitor XII, TWS119 is a cell-permeable agent shown to act as a potent inhibitor of GSK-3β
Definition
ChEBI: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles.
General Description
A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).
Biological Activity
Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
Biochem/physiol Actions
TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.
storage
Store at +4°C
References
[1] ding s, wu t y h, brinker a, et al. synthetic small molecules that control stem cell fate. proceedings of the national academy of sciences, 2003, 100(13): 7632-7637.
[2] wu t y h, ding s. applying chemical tools to the discovery of novel regenerative medicine. drug discovery today: technologies, 2006, 3(3): 255-260.
Properties of GSK-3BETA INHIBITOR XII
Melting point: | 249 °C |
Density | 1.42 |
storage temp. | 2-8°C |
solubility | insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO |
pka | 8.99±0.10(Predicted) |
form | powder |
color | white to beige |
Safety information for GSK-3BETA INHIBITOR XII
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for GSK-3BETA INHIBITOR XII
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