Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listGSK-3β Inhibitor XVIII

GSK-3β Inhibitor XVIII

Synonym(s):2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem

  • CAS NO.:1139875-74-3
  • Empirical Formula: C20H20ClN5OS
  • Molecular Weight: 413.92
  • MDL number: MFCD32671859
  • Update Date: 2024-07-02 08:55:11
GSK-3β Inhibitor XVIII Structural

What is GSK-3β Inhibitor XVIII?

Description

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.

Properties of GSK-3β Inhibitor XVIII

Boiling point: 632.3±65.0 °C(Predicted)
Density  1.358±0.06 g/cm3(Predicted)
storage temp.  +2C to +8C
solubility  DMSO: soluble
pka 6?+-.0.10(Predicted)
form  White solid
color  White to off-white

Safety information for GSK-3β Inhibitor XVIII

Computed Descriptors for GSK-3β Inhibitor XVIII

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.