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HomeProduct name listGSK-3β Inhibitor XVIII

GSK-3β Inhibitor XVIII

Synonym(s):2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem

  • CAS NO.:1139875-74-3
  • Empirical Formula: C20H20ClN5OS
  • Molecular Weight: 413.92
  • MDL number: MFCD32671859
  • Update Date: 2024-07-02 08:55:11
GSK-3β Inhibitor XVIII Structural

What is GSK-3β Inhibitor XVIII?

Description

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.

Properties of GSK-3β Inhibitor XVIII

Boiling point: 632.3±65.0 °C(Predicted)
Density  1.358±0.06 g/cm3(Predicted)
storage temp.  +2C to +8C
solubility  DMSO: soluble
pka 6?+-.0.10(Predicted)
form  White solid
color  White to off-white

Safety information for GSK-3β Inhibitor XVIII

Computed Descriptors for GSK-3β Inhibitor XVIII

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